country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Referencia número: HY-181891

Copy Link Print Information

XAT-13

XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases.

Para uso exclusivo en investigación. No vendemos a pacientes.

No. CAS: 3107904-58-2
Fòrmula: C₂₀H₁₆O₅
Peso molecular:336.34

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

XAT-13 Chemical Structure

No. CAS: 3107904-58-2

Tamaño

Precio

Stock

Cantidad

Amount: USD 0.00

* Seleccione Cantidad antes de agregar artículos.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
Help & FAQs
Classifications
Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

MRGPRX2

Ver todos los productos específicos de isoformas Calcium Channel :

In Vitro

XAT-13 (up to 100 μmol/L) shows no cytotoxicity in LAD2 cells^[1].
XAT-13 (25-100 μmol/L) inhibits C48/80-induced β-hexosaminidase release from LAD2 cells in a dose-dependent manner, with an IC₅₀ of 57.27 ± 0.13 μmol/L, and is more potent than Imperatorin (HY-N0285)^[1].
XAT-13 (25-100 μmol/L) dose-dependently inhibits C48/80-induced intracellular calcium influx in MRGPRX2-HEK293 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

XAT-13 (4-16 mg/kg; p.o.) exhibits an inhibitory effect on C48/80-induced local allergy in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C48/80-induced local allergy^[1]
Dosage:

4, 8, 16 mg/kg
Administration:

p.o.
Result:

Attenuated the hind paws thickness.
Resulted in statistically significant differences in serum histamine levels.

Chemical Information

No. CAS 3107904-58-2
Peso molecular 336.34
Fòrmula C₂₀H₁₆O₅
SMILES

O=C1OC2=C(OCCCOC3=CC=CC=C3)C4=C(C=CO4)C=C2C=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang W, et al. Furanocoumarin derivatives inhibit MRGPRX2-mediated pseudo-allergy. Bioorg Med Chem Lett. 2026;135:130589. [Content Brief]

Calculators

Calculadora de molaridad

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculadora de dilución

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

MOQ

Minimum order quantity

100 mg

Obtener un presupuesto En stock

Other size

Obtener un presupuesto

Amount: USD 0.00

Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

Nombre del producto:
Referencia número:
Cantidad:
MCE Japan Authorized Agent:

Nombre del producto:
No. CAS:
Species:
Pureza:
Cantidad:

XAT-13

Ver todos los productos específicos de isoformas Calcium Channel

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

XAT-13 Related Classifications

HY-181891 Related Classifications