Zilovertamab vedotin
Based on 1 Customer Validation
Zilovertamab vedotin (VLS-101) is a novel antibody-drug conjugate comprising the humanized monoclonal antibody zilovertamab and and the anti-microtubule cytotoxin monomethyl vedotin. Zilovertamab vedotin binding to tumor cell ROR1 results in rapid internalization, trafficking to lysosomes, antibody–agent conjugate cleavage, and monomethyl vedotin release. Zilovertamab vedotin induces apoptosis. Zilovertamab vedotin can be used in research of cancer.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza: 99.77%
- Peso molecular:151000 (average)
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
- Pureza y Documentación
- Referencias
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Help & FAQs
Actividad biológica
Zilovertamab vedotin (VLS-101; 0-100 μg/mL) induces cytotoxicity in ROR1+ primary MCL cells in a dose-dependent manner[1].
Zilovertamab vedotin (24h; ibrutinib-sensitive (JeKo-1) and resistant (JeKo BTK KD_2) cell lines) induces cell apoptosis and cell cycle arrest at G2/M[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:NSG PDX mice models with dual resistance to ibrutinib and CAR T. A PDX model[1]
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Dosage:2.5 mg/kg
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Administration:intravenous injection; weekly, for 3 weeks
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Result:Eliminated subcutaneous tumor growth of BA-resistant PDX model (PDX-1).
Prolonged tumor bearing mouse survival.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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Appearance Liquid
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Peso molecular 151000 (average)
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Color Colorless to light yellow
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SMILES
[Zilovertamab vedotin]
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Synonyms
VLS-101; MK-2140
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Envío
Shipping with dry ice.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
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Ficha de datos (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Zilovertamab vedotin Related Classifications
HY-P99956 Related Classifications
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