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Referencia número: HY-185742

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ZW-251

ZW-251 is a glypican-3 (GPC3)-targeted antibody-drug conjugate (ADC) with topoisomerase-I inhibitory activity. ZW-251 induces cytotoxicity, penetrates tumor spheroids, exerts bystander cytotoxicity, and inhibits tumor growth in hepatocellular carcinoma models. ZW-251 can be used for the research of hepatocellular carcinoma.

Para uso exclusivo en investigación. No vendemos a pacientes.

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

ZW-251 Chemical Structure

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Pureza y Documentación
Referencias
Calculators
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Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Topoisomerase I

Ver todos los productos específicos de isoformas Topoisomerase :

In Vitro

ZW-251 (0.001-100 nM; 4 days) exhibits cell cytotoxicity to HepG2 spheroid liver cancer cell line^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2
Cynomolgus Monkey^[2]	20 mg/kg	i.v.	110.4 h
Cynomolgus Monkey^[2]	60 mg/kg	i.v.	115.2 h
Cynomolgus Monkey^[2]	120 mg/kg	i.v.	129.6 h

In Vivo

ZW-251 (20-120 mg/kg; i.v.; 3 doses at day 1, 22 and 43) is well tolerated in cynomolgus monkeys and exhibits dose-proportional PK^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Cynomolgus monkeys
^[2]
Dosage:

20 mg/kg; 60 mg/kg; 120 mg/kg
Administration:

i.v.; 3 doses at day 1, 22 and 43
Result:

Was well tolerated in cynomolgus monkeys.
Exhibited dose-proportional PK.

Chemical Information

SMILES

[ZW-251]
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Instrucciones de manejo (2659 KB)

Referencias

[1]. Chandana, et al. A phase 1, first-in-human, multicenter study of ZW251, a novel glypican-3 (GPC3)–targeted antibody-drug conjugate (ADC), in participants with hepatocellular carcinoma (HCC). J Clin Oncol. 2026 Jan 12;44(Number 2_Suppl):TPS608.

[2]. Madera L, et al. ZW251, a novel glypican-3-targeting antibody-drug conjugate bearing a topoisomerase I inhibitor payload, demonstrates compelling preclinical activity in hepatocellular carcinoma models. 2024.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Actividad biológica
- Descripciòn
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Pureza y Documentación
Referencias

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ZW-251

Ver todos los productos específicos de isoformas Topoisomerase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

ZW-251 Related Classifications

HY-185742 Related Classifications