2. Gene
  3. CLOCK - clock circadian regulator Gene

CLOCK - clock circadian regulator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Bos taurus
Gene ID: 100300400 | Gene type: protein coding

About CLOCK

Summary

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding Histone Acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. [provided by RefSeq, Feb 2014]

CLOCK Products(1)

mRNA Protein Name
NM_001289769.1 NP_001276698.1 circadian locomoter output cycles protein kaput
Protein Preferred Names Protein Names

circadian locomoter output cycles protein kaput

clock homolog

Related Agents

Pre-clinical Phase
Bioactive Molecules (12)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-148765 CLK8 Inhibitor 98.06% Unkown
HY-115672 KS15 Inhibitor 99.46% Unkown
HY-115519 (E/Z)-GO289 Inhibitor 98.98% Unkown
HY-134194 KL201 98.18% Unkown
HY-119506 KL044 99.50% Unkown
HY-145149 Duostatin 5 99.76% Unkown
HY-RS02828 CLOCK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17250 Clock Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W011425 NTPO / Unkown
HY-134193 KL101 / Unkown
HY-RS23704 Clock Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W928636 5'-O-DMTr-2'-O-4'-C-locked-5-Me-rC(Bz) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CLOCK NCBI NCBI:9575