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Cat. No.: HY-145149S

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Duostatin 5-¹³C,d₃

Duostatin 5-¹³C,d₃ is the ¹³C-labeled Duostatin 5 (HY-145149). Duostatin 5 is a ADC Cytotoxin designed based on MMAF (HY-15579) and can be used to synthesize ADCs. The preparation of Duostatin 5 has the advantages of fewer synthetic steps, simple operation, less difficulty in quality control, and more stable chemical synthesis process. Duostatin 5 can be linked to the antibody targeting 5T4 (ZV05) by cross-linking with interchain cysteines through a disubstituted C-Lock linker. Duostatin 5 is a click chemistry reagent. It contains an azide group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing alkyne groups. It can also undergo ring strain-driven alkyne-azide cycloaddition (SPAAC) with molecules containing DBCO or BCN groups[1][2].

For research use only. We do not sell to patients.

Formula: C₃₉¹³CH₆₆D₃N₉O₆
Molecular Weight:776.04

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Duostatin 5-¹³C,d₃ Chemical Structure

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Biological Activity
- Description
- In Vitro
- Application
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

All ADC Payloads Isoforms :

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 2124210-34-8
Molecular Weight 776.04
Formula C₃₉¹³CH₆₆D₃N₉O₆
SMILES

CC(C)[C@H](NC([C@@H](N(C)[13C]([2H])([2H])[2H])C(C)C)=O)C(N([C@@H]([C@@H](C)CC)[C@H](OC)CC(N1[C@H]([C@H](OC)[C@@H](C)C(N[C@H](CN=[N+]=[N-])CC2=CC=C(N)C=C2)=O)CCC1)=O)C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.