2. Gene
  3. Mir27a - microRNA 27a Gene

Mir27a - microRNA 27a Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-27a

Gene ID: 100314006 | Gene type: ncRNA

About Mir27a

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
29373037 RGD
involved in lactation IEP
IEP: Inferred from expression pattern
30698333 RGD
involved in response to muscle activity IEP
IEP: Inferred from expression pattern
21709209 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N0909 Notoginsenoside R2 99.80% Unkown
HY-R00498 hsa-miR-27a-3p mimic 90.26% Unkown
HY-R00499 hsa-miR-27a-5p mimic 97.37% Unkown
HY-RI00499 hsa-miR-27a-5p inhibitor 98.96% Unkown
HY-RI00498 hsa-miR-27a-3p inhibitor 99.70% Unkown
HY-R00499A hsa-miR-27a-5p agomir 95.04% Unkown
HY-RI00498A hsa-miR-27a-3p antagomir 99.75% Unkown
HY-R00498A hsa-miR-27a-3p agomir / Unkown
HY-RI00499A hsa-miR-27a-5p antagomir / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir27a NCBI NCBI:407018