2. Gene
  3. Mir140 - microRNA 140 Gene

Mir140 - microRNA 140 Gene

  • Gene
  • Agent
  • Ortholog
Rattus norvegicus

Also known as rno-mir-140

Gene ID: 100314276 | Gene type: ncRNA

About Mir140

Summary

MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]

Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables MAP kinase kinase activity IMP
IMP: Inferred from mutant phenotype
28922712 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to hypoxia IEP
IEP: Inferred from expression pattern
28922712 RGD
involved in negative regulation of interleukin-1 beta production IMP
IMP: Inferred from mutant phenotype
31376096 RGD
involved in negative regulation of interleukin-6 production IMP
IMP: Inferred from mutant phenotype
31376096 RGD
involved in negative regulation of reactive oxygen species biosynthetic process IMP
IMP: Inferred from mutant phenotype
32519270 RGD
involved in negative regulation of toll-like receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
31376096 RGD
involved in negative regulation of tumor necrosis factor production IMP
IMP: Inferred from mutant phenotype
31376096 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-R00273 hsa-miR-140-5p mimic 96.0% Unkown
HY-R00272 hsa-miR-140-3p mimic 99.20% Unkown
HY-R00273A hsa-miR-140-5p agomir 98.33% Unkown
HY-RI00272 hsa-miR-140-3p inhibitor / Unkown
HY-RI00273A hsa-miR-140-5p antagomir 91.48% Unkown
HY-R00272A hsa-miR-140-3p agomir / Unkown
HY-RI00272A hsa-miR-140-3p antagomir / Unkown
HY-RI00273 hsa-miR-140-5p inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mir140 NCBI NCBI:406932