MIR140 - microRNA 140 Gene
Also Known as SEDN; MIRN140; mir-140; miRNA140
Species: Homo sapiens
About MIR140
This gene has 1 transcript (splice variant), 164 orthologues and is associated with 2 phenotypes.
Summary
MicroRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted MicroRNA stem-loop. [provided by RefSeq, Sep 2009]
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables mRNA 3'-UTR binding |
IDA
IDA: Inferred from direct assay
|
24530397 | GOA |
| enables mRNA base-pairing translational repressor activity |
IDA
IDA: Inferred from direct assay
|
23401231 | GOA |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Spondyloepiphyseal Dysplasia, Nishimura Type |
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| Spondyloepiphyseal Dysplasia-Craniosynostosis-Cleft Palate-Cataracts-Intellectual Disability Syndrome |
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| Osteogenic Sarcoma |
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| Lipoprotein Quantitative Trait Locus |
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| Diabetes Mellitus |
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| Colorectal Cancer |
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| Non-Alcoholic Fatty Liver Disease |
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| Lymphoma, Hodgkin, Classic |
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| Testicular Germ Cell Tumor |
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| Autism Spectrum Disorder |
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| Spinal Chordoma |
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| Myeloma, Multiple |
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| Oral Squamous Cell Carcinoma |
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| Leukemia, Chronic Lymphocytic |
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| Glioma |
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| Melanoma |
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| Bone Inflammation Disease |
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| Bone Resorption Disease |
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| Bone Remodeling Disease |
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| Lung Cancer |
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| Chordoma |
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| Cartilage Disease |
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| Pre-Malignant Neoplasm |
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| Fetal Alcohol Spectrum Disorder |
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| Embryonal Testis Carcinoma |
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| Connective Tissue Cancer |
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| Bone Structure Disease |
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| Respiratory System Cancer |
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| Larynx Cancer |
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| Bone Sarcoma |
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| Ischemic Bone Disease |
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| Respiratory System Disease |
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| Thoracic Cancer |
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| Acquired Metabolic Disease |
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| Stomach Disease |
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| Autoimmune Disease Of Musculoskeletal System |
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| Carbohydrate Metabolic Disorder |
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| Osteoarthritis |
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| Large Intestine Cancer |
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| Gastrointestinal System Cancer |
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| Glucose Metabolism Disease |
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| Skin Carcinoma |
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| Upper Respiratory Tract Disease |
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| Retinitis Pigmentosa 11 |
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| Gastrointestinal System Disease |
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| Bone Marrow Cancer |
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| Inherited Metabolic Disorder |
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| Sensory System Disease |
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| Nasopharyngeal Disease |
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| Immune System Disease |
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| Bile Duct Cancer |
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| Female Reproductive System Disease |
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| Pharynx Cancer |
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| Lymphatic System Cancer |
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| Bile Duct Adenocarcinoma |
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| Colonic Disease |
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| Lipomatosis, Multiple Symmetric |
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| Endocrine Gland Cancer |
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| Intestinal Disease |
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| Esophageal Disease |
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| Bone Deterioration Disease |
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| Endocrine System Disease |
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| Reproductive System Disease |
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| Myotonic Disease |
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| Cervix Disease |
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| Spinal Disease |
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| Laryngeal Disease |
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| Overnutrition |
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| Lymphatic System Disease |
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| Physical Disorder |
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| Fatty Liver Disease |
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| Cleft Palate, Isolated |
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| Uterine Anomalies |
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| Ossification Of The Posterior Longitudinal Ligament Of Spine |
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| Arteries, Anomalies Of |
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| Oral Cavity Cancer |
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| Bile Duct Disease |
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| Retinal Disease |
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| Bone Cancer |
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| Orofacial Cleft |
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| Liver Disease |
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| Bone Development Disease |
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| Nasopharyngeal Carcinoma |
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| Leukocyte Disease |
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| Bladder Disease |
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| Disease Of Mental Health |
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| Integumentary System Disease |
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| Biliary Tract Disease |
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| Specific Developmental Disorder |
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| Urinary System Disease |
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| Ovarian Disease |
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| Degenerative Disc Disease |
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| Osteoporosis |
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| Pleuropulmonary Blastoma |
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| Ocular Cancer |
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| Male Reproductive Organ Cancer |
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| Breast Disease |
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| Biliary Tract Cancer |
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| Bronchial Disease |
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| Central Nervous System Cancer |
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| Esophageal Cancer |
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| Male Reproductive System Disease |
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| Phenylketonuria |
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| Cervical Cancer |
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| Central Nervous System Disease |
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| Ovary Epithelial Cancer |
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| Muscular Disease |
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| Pancreas Disease |
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| Thymus Gland Disease |
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| Retinal Cancer |
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| Thymus Cancer |
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| Malignant Astrocytoma |
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| Connective Tissue Disease |
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| Bone Disease |
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| Mature B-Cell Neoplasm |
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| Renal Cell Carcinoma, Nonpapillary |
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| Prostate Disease |
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| Retinal Vascular Disease |
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| Cervix Carcinoma |
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| Head And Neck Cancer |
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| Malignant Ovarian Surface Epithelial-Stromal Neoplasm |
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| Myotonic Dystrophy 1 |
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| Amino Acid Metabolic Disorder |
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| Hematologic Cancer |
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| Lung Squamous Cell Carcinoma |
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| Mouth Disease |
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| Cerebrovascular Disease |
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| Osteochondrodysplasia |
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| Cell Type Benign Neoplasm |
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| Chromosomal Disease |
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| Melanoma, Uveal |
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| Lipid Storage Disease |
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| Muscle Tissue Disease |
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| Malignant Exocrine Pancreas Neoplasm |
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| Disease By Infectious Agent |
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| Uveal Disease |
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| Nervous System Disease |
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| Eye Disease |
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| Lymphoma, Non-Hodgkin, Familial |
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| Cardiovascular System Disease |
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| Pervasive Developmental Disorder |
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| Rectum Cancer |
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| Hepatocellular Carcinoma |
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| Heart Valve Disease |
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| Autoimmune Disease Of Central Nervous System |
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| Plasma Cell Neoplasm |
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| Peripheral Nervous System Disease |
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| Chromosomal Deletion Syndrome |
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| Heart Disease |
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| Brain Cancer |
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| Eye Degenerative Disease |
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| Immune Deficiency Disease |
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| Skin Disease |
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| Interstitial Lung Disease 2 |
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| Lung Cancer Susceptibility 3 |
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| Body Mass Index Quantitative Trait Locus 11 |
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| Leukemia, Acute Myeloid |
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| Attention Deficit-Hyperactivity Disorder |
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| Breast Cancer |
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| Basal Cell Carcinoma |
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| Leukemia, Chronic Myeloid |
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| Hypertrophic Cardiomyopathy |
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| Type 2 Diabetes Mellitus |
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| Dilated Cardiomyopathy |
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| Alzheimer Disease, Familial, 1 |
|
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| Myopathy |
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| Amyotrophic Lateral Sclerosis 1 |
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| Retinitis Pigmentosa |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | MIR140 | RGD | RGD:2325351 |
| Mus musculus | MIR140 | MGD | MGI:2676825 |