NRG3 - neuregulin 3 Gene

Also Known as HRG3; pro-NRG3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10718

About NRG3

Cytogenetic location: 10q23.1 Genomic coordinates (GRCh38): 10:81,875,194-82,987,179 (from NCBI)

This gene has 9 transcripts (splice variants), 211 orthologues and 3 paralogues. Biased expression in brain (RPKM 3.4), gall bladder (RPKM 0.5) and 1 other tissue.

Summary

This gene is a member of the neuregulin gene family. This gene family encodes ligands for the transmembrane tyrosine kinase receptors ERBB3 and ERBB4 - members of the epidermal growth factor receptor family. Ligand binding activates intracellular signaling cascades and the induction of cellular responses including proliferation, migration, differentiation, and survival or Apoptosis. This gene encodes neuregulin 3 (NRG3). NRG3 has been shown to activate the tyrosine phosphorylation of its cognate receptor, ERBB4, and is thought to influence neuroblast proliferation, migration and differentiation by signalling through ERBB4. NRG3 also promotes mammary differentiation during embryogenesis. Linkage studies have implicated this gene as a susceptibility locus for schizophrenia and schizoaffective disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described but their biological validity has not been verified.[provided by RefSeq, Sep 2009]

NRG3 Products (7)

mRNA	Protein	Name
NM_001010848.4	NP_001010848.2	pro-neuregulin-3, membrane-bound isoform isoform 1
NM_001165972.1	NP_001159444.1	pro-neuregulin-3, membrane-bound isoform isoform 2
NM_001165973.2	NP_001159445.1	pro-neuregulin-3, membrane-bound isoform isoform 3
NM_001370081.1	NP_001357010.1	pro-neuregulin-3, membrane-bound isoform isoform 4
NM_001370082.1	NP_001357011.1	pro-neuregulin-3, membrane-bound isoform isoform 5
NM_001370083.1	NP_001357012.1	pro-neuregulin-3, membrane-bound isoform isoform 6
NM_001370084.1	NP_001357013.1	pro-neuregulin-3, membrane-bound isoform isoform 7

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables receptor ligand activity	IDA IDA: Inferred from direct assay	12466964	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ERBB4 signaling pathway	IDA IDA: Inferred from direct assay	12466964	GOA
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	29114105	GOA
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	29114105	GOA

Cellular Component GO Annotation	Evidence	References	Source
is active in extracellular space	IDA IDA: Inferred from direct assay	12466964	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	29114105	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	29114105	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
pro-neuregulin-3, membrane-bound isoform	neuregulin-3-like polypeptide

Recombinant NRG3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75943	Neuregulin-3/NRG3 Protein, Human (HEK293, Fc)	B9EGV5 (E282-P342)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75944	Neuregulin-3/NRG3 Protein, Human (61a.a, HEK293, His, solution)	B9EGV5 (E282-P342)	≥ 95%, as determined by reducing SDS-PAGE.

NRG3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81687	NRG3 Antibody (YA1432)	WB	Human, Rat
HY-P81687A	NRG3 Antibody (YA1432)(PBS only)	WB	Human, Rat

Related Diseases

Diseases	Alias
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Schizoaffective Disorder	Schizo-Affective Psychosis Schizo-Affective Type Schizophrenia Schizoaffective Psychosis Schizoaffective Schizophrenia Schizophrenia, Schizo-Affective Type Schizophreniform Psychosis, Affective Type
Homocystinuria-Megaloblastic Anemia, Cblg Complementation Type	Methylcobalamin Deficiency, Cblg Type HMAG Methionine Synthase Deficiency Methylcobalamin Deficiency Type Cblg Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism, Cblg Complementation Type Homocystinuria-Megaloblastic Anemia Cblg Type Homocystinuria-Megaloblastic Anemia Due To Defect In Cobalamin Metabolism Cblg Complementation Type Methylcobalamin Deficiency Cbl G Type Homocystinuria Due To Defect In Methylation Cbl G Cblg Functional Methionine Synthase Deficiency Type Cblg Methylcobalamin Deficiency Cblg Type Arakawa Syndrome 2
Lissencephaly 2	Norman-Roberts Syndrome Lissencephaly Syndrome, Norman-Roberts Type LIS2 Lissencephaly With Cerebellar Hypoplasia Lch Lissencephaly Syndrome Norman-Roberts Type Norman Roberts Lissencephaly Syndrome Lissencephaly 3 Lis3 Microlissencephaly Type A Norman-Roberts Lissencephaly Syndrome Lissencephaly, Type 2 Cobblestone Lissencephaly
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09568	NRG3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174565	Human NRG3 mRNA		/	Unkown
HY-RS17691	Nrg3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24153	Nrg3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NRG3	MGD	MGI:1097165
Macaca mulatta	NRG3	VGNC	VGNC:103840
Felis catus	NRG3	VGNC	VGNC:97536
Canis familiaris	NRG3	VGNC	VGNC:51907
Bos taurus	NRG3	VGNC	VGNC:58396
Rattus norvegicus	NRG3	RGD	RGD:1559678
Others	NRG3	NCBI