NRG3 Antibody (YA1432)
(Synonyms: NRG3; Pro-neuregulin-3; membrane-bound isoform; Pro-NRG3)NRG3 Antibody (YA1432) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NRG3.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB
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Reactivity :
Human, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
NRG3 Antibody (YA1432) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NRG3.
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Host Rabbit
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Clonality Recombinant, Monoclonal
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Species ReactivityHuman, Rat
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Observed Molecular WeightObserved band size: 55 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 78 kDa
Entrez Gene: 10718 Human ; 18183 Mouse ; 498596 Rat
SwissProt: P56975 Human ; O35181 Mouse ;
OMIM: 605533 Human
A synthetic peptide of human NRG3
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Liquid
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
NRG3 is a Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes
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Subcellular Localization
Cell membrane; Single-pass type I membrane protein; Secreted; Cell membrane; Single-pass type I membrane protein
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Expression
Tissue_specificity:Highly expressed in most regions of the brain with the exception of corpus callosum. Expressed at lower level in testis. Not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes -
Isoforms & Post-Translational Modification
P56975 has 4 isomers: P56975-1: 77901 Da (predicted); P56975-2: 77164 Da (predicted); P56975-3: 56034 Da (predicted); P56975-4: 75031 Da (predicted).
Proteolytic cleavage close to the plasma membrane on the external face leads to the release of the soluble growth factor form;Extensive glycosylation precedes the proteolytic cleavage (By similarity). Isoform 3 is glycosylated -
Subunit
Interacts with ERBB4
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SwissProt ID
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Synonyms
NRG3; Pro-neuregulin-3; membrane-bound isoform; Pro-NRG3
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Research Field
Neuroscience
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