Eprs - glutamyl-prolyl-tRNA synthetase Gene

Also Known as Qprs; Eprs1; 2410081F06Rik; 3010002K18Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 107508

Summary

Enables proline-tRNA Ligase activity. Involved in several processes, including cellular response to Insulin stimulus; prolyl-tRNA aminoacylation; and regulation of long-chain fatty acid import into cell. Acts upstream of or within cellular response to interferon-gamma. Located in plasma membrane. Part of GAIT complex and Aminoacyl-tRNA Synthetase multienzyme complex. Is expressed in several structures, including alimentary system; axial skeleton; craniocervical region bone; face; and liver. Human ortholog(s) of this gene implicated in hypomyelinating leukodystrophy. Orthologous to human EPRS1 (glutamyl-prolyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]

Eprs Products (2)

mRNA Protein Name
NM_001357474.1 NP_001344403.1 bifunctional glutamate/proline--tRNA ligase isoform 2
NM_029735.2 NP_084011.1 bifunctional glutamate/proline--tRNA ligase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables proline-tRNA ligase activity IMP
IMP: Inferred from mutant phenotype
12060739 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
28178239 MGI
Biological Process GO Annotation Evidence References Source
involved in cellular response to insulin stimulus IMP
IMP: Inferred from mutant phenotype
28178239 MGI
involved in cellular response to type II interferon IDA
IDA: Inferred from direct assay
23071094 MGI
involved in negative regulation of translation IDA
IDA: Inferred from direct assay
23071094 MGI
involved in prolyl-tRNA aminoacylation IDA
IDA: Inferred from direct assay
12060739 MGI
involved in regulation of long-chain fatty acid import into cell IMP
IMP: Inferred from mutant phenotype
28178239 MGI
Cellular Component GO Annotation Evidence References Source
part of GAIT complex IDA
IDA: Inferred from direct assay
23071094 MGI
part of aminoacyl-tRNA synthetase multienzyme complex IDA
IDA: Inferred from direct assay
12060739 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
28178239 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional glutamate/proline--tRNA ligase

  • bifunctional aminoacyl-tRNA synthetase

  • glutamine-proline-tRNA synthetase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (16)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-136265 BC-LI-0186 Inhibitor 99.20% Unkown
HY-172279A DSPE-PEG2000-TAT 95.0% Unkown
HY-W131302 Ethylenediaminediacetic acid 98.0% Unkown
HY-147151 AMCPy / Unkown
HY-168943 PLGA nanoparticles, 100nm / Unkown
HY-168943A PLGA nanoparticles, 200nm / Unkown
HY-168943B PLGA nanoparticles, 500nm / Unkown
HY-180557 4A-BFA-11 / Unkown
HY-181464 CAY10565 Activator / Unkown
HY-181741 PI3K-001 / Unkown
HY-P11145 Influenza HA (529-537) / Unkown
HY-RS04451 EPRS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W777072 4-Isocyanato-TEMPO,Technical grade / Unkown
HY-117925 Personalised postprandial-targeting Inhibitor / Unkown
HY-168943C PLGA nanoparticles, 1μm / Unkown
HY-183004 NCP26 / Unkown