PLGA nanoparticles, 1μm
PLGA nanoparticles, 1μm, are biodegradable tumor-targeting nanocarriers that can serve as drug delivery enhancers and multidrug resistance inhibitors. PLGA nanoparticles, 1μm, passively enriched through the EPR effect and actively targeted via ligand-mediated endocytosis, can encapsulate various antitumor active molecules. PLGA nanoparticles, 1μm can specifically recognize multiple types of tumor cells and improve cellular uptake, cytotoxicity and antiproliferative effects after modification with ligands such as transferrin, folic acid, and RGD. PLGA nanoparticles, 1μm can encapsulate various therapeutic drugs and can be surface modified to achieve targeting, imaging, and prolonged circulation time, making them suitable for cancer-related research.
For research use only. We do not sell to patients.
- Formula: C7H12O4
- Molecular Weight:160.17
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
PLGA nanoparticles, 1μm loaded with Dexamethasone (HY-14648) completely inhibit the proliferation of vascular smooth muscle cells[2].
PLGA nanoparticles, 1μm can deliver various active substances including p53 plasmids, Curcumin (HY-N0005), cysteine protease inhibitors, Camptothecin (HY-16560), Doxorubicin (HY-15142A), Paclitaxel (HY-B0015), Cisplatin (HY-17394), and Rapamycin (HY-10219), enhance drug accumulation in multiple tumor and smooth muscle cells, and prolong the duration of action[2].
PLGA nanoparticles, 1μm show a slower initial in vitro degradation rate than 0.1 μm 50:50 PLGA nanoparticles, but a faster rate than 10 μm 50:50 PLGA microparticles; comparable degradation rates are observed for all three in the late stage of degradation[3].
PLGA nanoparticles, 1μm exhibit stronger bioadhesion to inflamed colonic mucosa than PLGA microspheres with a size of 10 μm, while PLGA nanoparticles with a smaller size (0.1 μm) show the strongest bioadhesion[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Molecular Weight 160.17
-
Formula C7H12O4
-
SMILES
CC(C)C(OCC(OC)=O)=O.[x].[y]
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Chiu HI, et al. Cytotoxicity of targeted PLGA nanoparticles: a systematic review. RSC advances. 2021 Mar 01;11(16):9433-9449. [Content Brief]
[2]. Acharya S. PLGA nanoparticles containing various anticancer agents and tumour delivery by EPR effect. Advanced drug delivery reviews. 2011 Mar 18;63(3):170-83. [Content Brief]
[3]. Bala I, et al. PLGA nanoparticles in drug delivery: the state of the art. Critical reviews in therapeutic drug carrier systems. 2004;21(5):387-422. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PLGA nanoparticles, 1μm Related Classifications
HY-168943C Related Classifications
Powered by Bioz