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TP53RK - TP53 regulating kinase Gene

Also Known as PRPK; BUD32; TPRKB; GAMOS4; Nori-2; Nori-2p; dJ101A2; C20orf64

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 112858

About TP53RK

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,684,365-46,689,444 (from NCBI)

This gene has 2 transcripts (splice variants), 211 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 5.4), thyroid (RPKM 5.0) and 25 other tissues.

Summary

Enables p53 binding activity and protein serine/threonine kinase activity. Involved in protein phosphorylation. Located in cytoplasm and nucleus. Part of EKC/KEOPS complex. Implicated in Galloway-Mowat syndrome 4. [provided by Alliance of Genome Resources, Apr 2022]

TP53RK Products (1)

mRNA	Protein	Name
NM_033550.4	NP_291028.3	EKC/KEOPS complex subunit TP53RK

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables p53 binding	IDA IDA: Inferred from direct assay	11546806	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11546806	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11546806	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11546806	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of EKC/KEOPS complex	IDA IDA: Inferred from direct assay	27903914	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	28805828	GOA
located in nucleus	IDA IDA: Inferred from direct assay	11546806	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53RK Protein Structure

Kdo

0
100
200
253 a.a.

Protein Preferred Names	Protein Names
EKC/KEOPS complex subunit TP53RK	atypical serine/threonine protein kinase TP53RK

TP53RK Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TP53RK	Q96S44	OSGEP	Homo sapiens	Q9NPF4	Anti Tag CoIP	28514442
Intra	TP53RK	Q96S44	OSGEP	Homo sapiens	Q9NPF4	Pull Down	32707033
Intra	TP53RK	Q96S44	OSGEP	Homo sapiens	Q9NPF4	Anti Tag CoIP	33961781
Intra	TP53RK	Q96S44	OSGEP	Homo sapiens	Q9NPF4	TAP	23455922
Intra	TP53RK	Q96S44	OSGEP	Homo sapiens	Q9NPF4	Y2H Fragment Pooling	23414517
Intra	TP53RK	Q96S44	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	TP53RK	Q96S44	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	32296183
Intra	TP53RK	Q96S44	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	32296183
Intra	TP53RK	Q96S44	CALCOCO2	Homo sapiens	Q13137	Y2H Array	31515488
Intra	TP53RK	Q96S44	CALCOCO2	Homo sapiens	Q13137	Validated Y2H	25416956
Intra	TP53RK	Q96S44	CALCOCO2	Homo sapiens	Q13137	Y2H Array	25416956
Intra	TP53RK	Q96S44	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	TP53RK	Q96S44	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956
Intra	TP53RK	Q96S44	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	TP53RK	Q96S44	TPRKB	Homo sapiens	Q9Y3C4	Pull Down	32707033
Intra	TP53RK	Q96S44	TPRKB	Homo sapiens	Q9Y3C4	Anti Tag CoIP	33961781
Intra	TP53RK	Q96S44	TPRKB	Homo sapiens	Q9Y3C4	Y2H Pooling	16189514
Intra	TP53RK	Q96S44	TPRKB	Homo sapiens	Q9Y3C4	TAP	23455922

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Galloway-Mowat Syndrome 4	GAMOS4
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Galloway-Mowat Syndrome 1	Galloway Syndrome Nephrosis-Neuronal Dysmigration Syndrome Nephrosis-Microcephaly Syndrome Camos Scar5 GAMOS1 Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Microcephaly, Hiatal Hernia And Nephrotic Syndrome Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly Scar5, Formerly Spinocerebellar Ataxia Autosomal Recessive 5 Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities Camos Syndrome Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome Galloway-Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 5 Galloway Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive 5
Galloway-Mowat Syndrome 2
Bladder Calculus	Urinary Bladder Calculi Urinary Bladder Stone Bladder Calculi Bladder Stone Urinary Bladder Calculus Vesical Calculi Vesical Calculus Vesicolithiasis Cystolithiasis Cystic Calculi Cystic Calculus
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Lower Urinary Tract Calculus	Calculus Of Lower Urinary Tract
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Polymicrogyria	Pmg
Deficiency Anemia	Anemia Deficiency Anemias Anaemia
Autosomal Recessive Intellectual Developmental Disorder	Mental Retardation, Autosomal Recessive Autosomal Recessive Mental Retardation Autosomal Recessive Non-Syndromic Mental Retardation Autosomal Recessive Non-Syndromic Intellectual Disability
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14922	TP53RK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TP53RK	VGNC	VGNC:108069
Rattus norvegicus	TP53RK	RGD	RGD:1591394
Mus musculus	TP53RK	MGD	MGI:1918294
Bos taurus	TP53RK	VGNC	VGNC:36238
Canis familiaris	TP53RK	VGNC	VGNC:47727
Others	TP53RK	NCBI