CHRNA3 - cholinergic receptor nicotinic alpha 3 subunit Gene

Also Known as LNCR2; PAOD2; BAIPRCK; NACHRA3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1136

About CHRNA3

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,593,052-78,620,996 (from NCBI)

This gene has 8 transcripts (splice variants), 207 orthologues, 45 paralogues and is associated with 3 phenotypes. Biased expression in adrenal (RPKM 16.5), appendix (RPKM 2.4) and 2 other tissues.

Summary

This locus encodes a member of the nicotinic acetylcholine receptor family of proteins. Members of this family of proteins form pentameric complexes comprised of both alpha and beta subunits. This locus encodes an alpha-type subunit, as it contains characteristic adjacent cysteine residues. The encoded protein is a ligand-gated ion channel that likely plays a role in neurotransmission. Polymorphisms in this gene have been associated with an increased risk of smoking initiation and an increased susceptibility to lung Cancer. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

CHRNA3 Products (2)

mRNA	Protein	Name
NM_000743.5	NP_000734.2	neuronal acetylcholine receptor subunit alpha-3 isoform 1 precursor
NM_001166694.2	NP_001160166.1	neuronal acetylcholine receptor subunit alpha-3 isoform 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables acetylcholine receptor activity	IDA IDA: Inferred from direct assay	8906617	GOA
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: Inferred from direct assay	8906617	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26265139	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in behavioral response to nicotine	IMP IMP: Inferred from mutant phenotype	18227835	GOA
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	11450844	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	8906617	GOA
involved in synaptic transmission involved in micturition	IMP IMP: Inferred from mutant phenotype	11450844	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of acetylcholine-gated channel complex	IDA IDA: Inferred from direct assay	8906617	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRNA3 Protein Structure

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
505 a.a.

Protein Preferred Names	Protein Names
neuronal acetylcholine receptor subunit alpha-3	cholinergic receptor, nicotinic alpha 3

Recombinant CHRNA3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72144	CHRNA3 Protein, Human (His-SUMO)	P32297 (S32-L240)	≥ 90%, as determined by reducing SDS-PAGE.

CHRNA3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P84262	CHRNA3 Antibody (YA3959)	ICC/IF, FC, ELISA	Human
HY-P84262A	CHRNA3 Antibody (YA3959)(PBS only)	ICC/IF, FC, ELISA	Human

Related Diseases

Diseases	Alias
Bladder Dysfunction, Autonomic, With Impaired Pupillary Reflex And Secondary Cakut	Urinary Bladder, Atony Of BAIPRCK Atony Of Urinary Bladder
Smoking As A Quantitative Trait Locus 3	Lung Cancer Susceptibility 2 Nicotine Dependence SQTL3 Nicotine Dependence, Susceptibility To
High Grade Glioma	Malignant Glioma Glial Cell Tumor Glioma, Malignant Malignant Neuroglial Tumor Neuroglial Tumor Glioma Malignant Gliomas
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Berdon Syndrome MMIHS Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Megacystis, Microcolon, Hypoperistalsis Syndrome Visceral Myopathy Mmih Syndrome Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome MMIHS1 Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih Mmhs
Amyotrophic Lateral Sclerosis 1	Amyotrophic Lateral Sclerosis ALS Lou Gehrig Disease Amyotrophic Lateral Sclerosis Type 1 Charcot Disease ALS1 Amyotrophic Lateral Sclerosis, Susceptibility To Fals Lou Gehrig'S Disease Mnd Motor Neuron Disease Familial Amyotrophic Lateral Sclerosis Amyotrophic Lateral Sclerosis 1, Familial Amyotrophic Lateral Sclerosis 1, Autosomal Dominant Motor Neuron Disease, Bulbar Motor Neurone Disease Amyotrophic Lateral Sclerosis With Dementia Dementia With Amyotrophic Lateral Sclerosis Motor Neuron Disease, Amyotrophic Lateral Sclerosis Sclerosis, Lateral, Amyotrophic Sclerosis, Lateral, Amyotrophic, Type 1 Amyotrophic Sclerosis Als - [Amyotrophic Lateral Sclerosis] Wasting Palsy Amyotrophic Paralysis Amyotrophy Lateral Sclerosis Wasting Paralysis Spinal Progressive Amyotrophy Progressive Atrophic Paralysis
Dyskeratosis Congenita, Autosomal Dominant 2	Autosomal Recessive Dyskeratosis Congenita 4 DKCA2 Autosomal Dominant Dyskeratosis Congenita 2 DKCB4 Dyskeratosis Congenita, Autosomal Dominant, 2 Dyskeratosis Congenita Scoggins Type Dyskeratosis Congenita, Autosomal Recessive, 4 Dyskeratosis Congenita, Autosomal Recessive 4 Dyskeratosis Congenita, Autosomal Dominant, Type 2
Alpha-1-Antitrypsin Deficiency	Alpha 1-Antitrypsin Deficiency Alpha-1 Antitrypsin Deficiency Aat Deficiency Aatd A1ATD Emphysema Due To Aat Deficiency A1at Deficiency Emphysema-Cirrhosis, Due To Aat Deficiency Hemorrhagic Diathesis Due To Antithrombin Pittsburgh Alpha-1 Antiprotease Deficiency Alpha 1 Antitrypsin Deficiency Aat Alpha-1 Protease Inhibitor Deficiency Alpha-1 Related Emphysema Genetic Emphysema Hereditary Pulmonary Emphysema Inherited Emphysema Alpha-1-Proteinase Inhibitor Deficiency Alpha1-Antitrypsin Deficiency Alpha-1-Antitrypsin Deficiency, Autosomal Recessive Emphysema, Hereditary Pulmonary Aatd - [Alpha-1-Antitrypsin] Deficiency
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Tobacco Addiction	Nicotine Dependence Tobacco Addiction, Susceptibility To Nicotine Addiction Tobacco Use Disorder Smoking Habit Nicotine Dependence, Protection Against Nicotine Addiction, Protection From Cigarette Habituation Cigarette Habituation, Susceptibility To Smoking Habit, Susceptibility To Nicotine Dependence, Susceptibility To Nicotine Addiction, Susceptibility To Addiction, Tobacco, Susceptibility To Compulsive Tobacco User Syndrome Tobacco Dependence Tobacco Dependence Syndrome Cigarette Addiction Cigarette Dependence Smoking Addiction Smokers Syndrome
Substance Dependence
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Vesicoureteral Reflux	Vesico-Ureteral Reflux
Cocaine Dependence
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy	Adnfle Autosomal Dominant Sleep-Related Hypermotor Epilepsy Enfl Benign Familial Infantile Seizures 6 Benign Familial Infantile Seizures, 6 Nocturnal Frontal Lobe Epilepsy-4 Enfl1 Epilepsy, Nocturnal Frontal Lobe, 1 Epilepsy, Nocturnal Frontal Lobe, Type 1
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02668	CHRNA3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20143	Chrna3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26647	Chrna3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CHRNA3	RGD	RGD:2345
Canis familiaris	CHRNA3	VGNC	VGNC:39238
Felis catus	CHRNA3	VGNC	VGNC:60880
Mus musculus	CHRNA3	MGD	MGI:87887
Bos taurus	CHRNA3	VGNC	VGNC:27325
Macaca mulatta	CHRNA3	VGNC	VGNC:71047
Others	CHRNA3	NCBI