CEP20 - centrosomal protein 20 Gene

Also Known as FOPNL; FOR20; C16orf63; PHSECRG2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 123811

About CEP20

Cytogenetic location: 16p13.11 Genomic coordinates (GRCh38): 16:15,865,719-15,888,603 (from NCBI)

This gene has 9 transcripts (splice variants), 1 gene allele and 196 orthologues. Ubiquitous expression in thyroid (RPKM 17.8), esophagus (RPKM 13.1) and 25 other tissues.

Summary

Enables identical protein binding activity. Involved in cilium assembly. Located in centriolar satellite and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CEP20 Products (6)

mRNA Protein Name
NM_001304497.2 NP_001291426.1 centrosomal protein 20 isoform 2
NM_001304498.2 NP_001291427.1 centrosomal protein 20 isoform 3
NM_001304499.2 NP_001291428.1 centrosomal protein 20 isoform 4
NM_001304500.2 NP_001291429.1 centrosomal protein 20 isoform 5
NM_001304502.2 NP_001291431.1 centrosomal protein 20 isoform 6
NM_144600.4 NP_653201.1 centrosomal protein 20 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
20551181 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cilium assembly IMP
IMP: Inferred from mutant phenotype
15616553 GOA
Cellular Component GO Annotation Evidence References Source
located in centriolar satellite IDA
IDA: Inferred from direct assay
15616553 GOA
located in centrosome IDA
IDA: Inferred from direct assay
21399614 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CEP20 Protein Structure

FOP_dimer

FOP_dimer: FOP N terminal dimerisation domain (50 - 113)

  • 0
  • 100
  • 174 a.a.
Protein Preferred Names Protein Names

centrosomal protein 20

  • FGFR1OP N-terminal like

CEP20 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CEP20 Q96NB1 OFD1 Homo sapiens O75665
Anti Tag CoIP
33961781
Intra
CEP20 Q96NB1 CEP20 Homo sapiens Q96NB1
FPS
31837246
Intra
CEP20 Q96NB1 PCM1 Homo sapiens Q15154
Confocal
20551181
Intra
CEP20 Q96NB1 CEP20 Homo sapiens Q96NB1
Anti Tag CoIP
20551181
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Orofaciodigital Syndrome I

  • OFD1

  • Orofaciodigital Syndrome 1

  • Oral-Facial-Digital Syndrome, Type I

  • Oral-Facial-Digital Syndrome 1

  • Ofds I

  • Papillon-Leage And Psaume Syndrome

  • Papillon-Leage-Psaume Syndrome

  • Oral-Facial-Digital Syndrome Type 1

  • Orofaciodigital Syndrome Type 1

  • Orofaciodigital Syndromes

  • Orofaciodigital Syndrome Type I

  • Oral-Facial-Digital Syndrome Type I

  • Ofd Syndrome 1

  • Ofds 1

  • Oral Facial Digital Syndrome 1

  • Oral Facial Digital Syndrome Type 1

  • Papillon-League-Psaume Syndrome

  • Ofdi

  • Ofdsi

  • Orofaciodigital Syndrome, Type I
Orofaciodigital Syndrome

  • Oral-Facial-Digital Syndrome

  • Orofaciodigital Syndromes

  • Ofd

  • Oral Facial Digital Syndromes

  • Oral-Facial-Digital Syndromes

  • Dysplasia Linguofacialis

  • Ofds

  • Oro-Facio-Digital Syndrome

  • Orodigitofacial Dysostosis

  • Orodigitofacial Syndrome

  • Oral Facial Digital Syndrome

  • Orofaciodigital Syndrome I
Lissencephaly

  • Pachygyria

  • Broad Gyri Of Cerebrum

  • Large Gyri Of Cerebrum

  • Macrogyria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-W286743 Nε-(Carboxymethyl)-L-lysine Activator 99.70% Phase 3

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02509 CEP20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CEP20 VGNC VGNC:40939
Macaca mulatta CEP20 VGNC VGNC:99500
Bos taurus CEP20 VGNC VGNC:29072
Rattus norvegicus CEP20 RGD RGD:1305823
Mus musculus CEP20 MGD MGI:1913336
Felis catus CEP20 VGNC VGNC:80574
Others CEP20 NCBI