GPR139 - G protein-coupled receptor 139 Gene

Also Known as PGR3; GPRg1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 124274

About GPR139

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,028,239-20,073,890 (from NCBI)

This gene has 2 transcripts (splice variants), 335 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GPR139 Products (2)

mRNA	Protein	Name
NM_001002911.4	NP_001002911.1	probable G-protein coupled receptor 139 isoform 1
NM_001318483.1	NP_001305412.1	probable G-protein coupled receptor 139 isoform 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	15845401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR139 Protein Structure

7tm_1

0
100
200
300
353 a.a.

Protein Preferred Names	Protein Names
probable G-protein coupled receptor 139	G protein-coupled receptor PGR3 g(q)-coupled orphan receptor GPRg1

Related Diseases

Diseases	Alias
Isolated Growth Hormone Deficiency, Type Ib	Isolated Growth Hormone Deficiency Type Ib IGHD1B Ighd Ib Growth Hormone Deficiency, Isolated, Type Ib Congenital Ighd Type Ib Congenital Isolated Gh Deficiency Type Ib Congenital Isolated Growth Hormone Deficiency Type Ib Dwarfism Of Sindh Pituitary Dwarfism I Isolated Growth Hormone Deficiency Type 1b Ighd 1b Growth Hormone Deficiency, Isolated, 1b

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-132228	Zelatriazin	Agonist	99.88%	Phase 2

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19838	JNJ-63533054	Agonist	99.80%	Unkown
HY-128057	NCRW0005-F05	Antagonist	99.94%	Unkown
HY-119168	LP-471756	Antagonist	99.53%	Unkown
HY-101777	TC-O 9311	Agonist	99.83%	Unkown
HY-149651	GPR139 agonist-2	Agonist	99.85%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	GPR139	VGNC	VGNC:41400
Macaca mulatta	GPR139	VGNC	VGNC:104730
Rattus norvegicus	GPR139	RGD	RGD:1311729
Mus musculus	GPR139	MGD	MGI:2685341
Felis catus	GPR139	VGNC	VGNC:80578
Bos taurus	GPR139	VGNC	VGNC:29553
Others	GPR139	NCBI