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NR2C2AP - nuclear receptor 2C2 associated protein Gene

Also Known as TRA16

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 126382

About NR2C2AP

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:19,201,409-19,203,414 (from NCBI)

This gene has 7 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in ovary (RPKM 9.3), skin (RPKM 8.7) and 25 other tissues.

Summary

Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

NR2C2AP Products (2)

mRNA	Protein	Name
NM_001300945.2	NP_001287874.1	nuclear receptor 2C2-associated protein isoform 1
NM_176880.6	NP_795361.1	nuclear receptor 2C2-associated protein isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12486131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NR2C2AP Protein Structure

F5_F8_type_C

0
100
139 a.a.

Protein Preferred Names	Protein Names
nuclear receptor 2C2-associated protein	TR4 orphan receptor associated protein TRA16

NR2C2AP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864-2	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864-2	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	TEPSIN	Homo sapiens	Q96N21	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	VPS52	Homo sapiens	Q8N1B4	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	REL	Homo sapiens	Q04864	Y2H Prey Pooling	25416956
Intra	NR2C2AP	Q86WQ0	TCF4	Homo sapiens	P15884	Validated Y2H	25416956
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	NR2C2AP	Q86WQ0	DDIT4L	Homo sapiens	Q96D03	Y2H Array	32296183
Intra	NR2C2AP	Q86WQ0	SLC16A3	Homo sapiens	O15427	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Bare Lymphocyte Syndrome, Type Ii	Mhc Class Ii Deficiency Bare Lymphocyte Syndrome Major Histocompatibility Complex Class Ii Deficiency Bare Lymphocyte Syndrome 2 Bare Lymphocyte Syndrome Type 2 Severe Combined Immunodeficiency, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group C Bare Lymphocyte Syndrome, Type Ii, Complementation Group D Bare Lymphocyte Syndrome Type Ii Scid, Hla Class Ii-Negative Bare Lymphocyte Syndrome, Type Ii, Complementation Group A Bare Lymphocyte Syndrome, Type Ii, Complementation Group B Scid Due To Absent Class Ii Hla Antigens Hla Class 1 Deficiency Scid, Hla Class 2-Negative Bls Type Ii Bare Lymphocyte Syndrome Type 2, Complementation Group A Bare Lymphocyte Syndrome Type 2, Complementation Group E Severe Combined Immunodeficiency Bls, Type Ii Bls Bare Lymphocyte Syndrome, Type Ii, Complementation Group E Blsii Bls Type 1 Bls 2 Scid Due To Absence Of Class Ii Hla Antigens Severe Combined Immunodeficiency Due To Absent Class Ii Human Leukocyte Antigens Immunodeficiency By Defective Expression Of Mhc Class Ii BLS2 Bare Lymphocyte Syndrome Type Ii Complementation Group A Bare Lymphocyte Syndrome Type Ii Complementation Group B Bare Lymphocyte Syndrome Type Ii Complementation Group C Bare Lymphocyte Syndrome Type Ii Complementation Group D Bare Lymphocyte Syndrome Type Ii Complementation Group E Bls Ii Hereditary Mhc Class Ii Deficiency Hla Class Ii Deficient Combined Immunodeficiency Mhc-Ii Deficiency Scid Hla Class Ii-Negative Severe Combined Immunodeficiency Hla Class Ii-Negative Bl-2 Immunodeficiency By Defective Expression Of Hla Class 2 Hla Class 2-Negative Severe Combined Immunodeficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09538	NR2C2AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR2C2AP	VGNC	VGNC:32237
Macaca mulatta	NR2C2AP	VGNC	VGNC:75495
Felis catus	NR2C2AP	VGNC	VGNC:63877
Rattus norvegicus	NR2C2AP	RGD	RGD:1561190
Mus musculus	NR2C2AP	MGD	MGI:1922942
Canis familiaris	NR2C2AP	VGNC	VGNC:43948
Others	NR2C2AP	NCBI