FAM3D - FAM3 metabolism regulating signaling molecule D Gene

Also Known as EF7; OIT1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 131177

About FAM3D

Cytogenetic location: 3p14.2 Genomic coordinates (GRCh38): 3:58,633,946-58,666,774 (from NCBI)

This gene has 5 transcripts (splice variants), 128 orthologues and 3 paralogues. Biased expression in colon (RPKM 146.4), salivary gland (RPKM 60.2) and 6 other tissues.

Summary

Involved in negative regulation of Insulin secretion. Predicted to be located in extracellular region. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

FAM3D Products (1)

mRNA Protein Name
NM_138805.3 NP_620160.1 protein FAM3D precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of insulin secretion IDA
IDA: Inferred from direct assay
12160727 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein FAM3D

  • Oncoprotein-induced transcript 1

FAM3D Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
FAM3D Q96BQ1 PKD2 Homo sapiens Q13563
Anti Tag CoIP
28514442
Intra
FAM3D Q96BQ1 PKD2 Homo sapiens Q13563
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FAM3D Proteins

Cat. No. Product Name Accession Purity
HY-P70890 FAM3D Protein, Human (HEK293, His) Q96BQ1 (Y26-F224) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia 4

  • DBA4

  • Rps17-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 4
Deafness, Autosomal Recessive 17

  • DFNB17

  • Autosomal Recessive Nonsyndromic Deafness 17

  • Autosomal Recessive Deafness 17
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04714 FAM3D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18063 Fam3d Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24538 Fam3d Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FAM3D VGNC VGNC:62113
Bos taurus FAM3D VGNC VGNC:28812
Canis familiaris FAM3D VGNC VGNC:40680
Macaca mulatta FAM3D VGNC VGNC:110366
Mus musculus FAM3D MGD MGI:1201784
Rattus norvegicus FAM3D RGD RGD:1305512
Others FAM3D NCBI