MPLKIP - M-phase specific PLK1 interacting protein Gene

Also Known as ABHS; TTD4; ORF20; C7orf11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 136647

About MPLKIP

Cytogenetic location: 7p14.1 Genomic coordinates (GRCh38): 7:40,126,027-40,134,622 (from NCBI)

This gene has 1 transcript (splice variant), 149 orthologues and is associated with 4 phenotypes. Ubiquitous expression in liver (RPKM 18.5), kidney (RPKM 17.4) and 25 other tissues.

Summary

The protein encoded by this gene localizes to the centrosome during Mitosis and to the midbody during cytokinesis. The protein is phosphorylated by cyclin-dependent kinase 1 during Mitosis and subsequently interacts with polo-like kinase 1. The protein is thought to function in regulating Mitosis and cytokinesis. Mutations in this gene result in nonphotosensitive trichothiodystrophy. [provided by RefSeq, Nov 2009]

MPLKIP Products (1)

mRNA Protein Name
NM_138701.4 NP_619646.1 M-phase-specific PLK1-interacting protein

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17310276 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
17310276 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
17310276 GOA
located in midbody IDA
IDA: Inferred from direct assay
17310276 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17310276 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MPLKIP Protein Structure

MPLKIP

MPLKIP: M-phase-specific PLK1-interacting protein (43 - 169)

  • 0
  • 100
  • 179 a.a.
Protein Preferred Names Protein Names

M-phase-specific PLK1-interacting protein

  • Russell-Silver syndrome region

MPLKIP Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MPLKIP Q8TAP9 AKAP8L Homo sapiens Q9ULX6
Validated Y2H
32296183
Intra
MPLKIP Q8TAP9 AKAP8L Homo sapiens Q9ULX6
Y2H Array
32296183
Intra
MPLKIP Q8TAP9 AKAP8L Homo sapiens Q9ULX6
Y2H Prey Pooling
32296183
Intra
MPLKIP Q8TAP9 GORASP2 Homo sapiens Q9H8Y8
Y2H Prey Pooling
32296183
Intra
MPLKIP Q8TAP9 GORASP2 Homo sapiens Q9H8Y8
Validated Y2H
32296183
Intra
MPLKIP Q8TAP9 GORASP2 Homo sapiens Q9H8Y8
Y2H Array
32296183
Intra
MPLKIP Q8TAP9 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Trichothiodystrophy 4, Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome

  • TTD4

  • Trichothiodystrophy, Nonphotosensitive 1

  • Hair-Brain Syndrome

  • Bids Syndrome

  • Ttdn1

  • Abhs

  • Pollitt Syndrome

  • Trichothiodystrophy-Neurocutaneous Syndrome

  • Nonphotosensitive Trichothiodystrophy 4

  • Trichorrhexis Nodosa Syndrome

  • Trichothiodystrophy 4, Non-Photosensitive

  • Trichothiodystrophy Non-Photosensitive 1
Nonphotosensitive Trichothiodystrophy

  • Trichothiodystrophy Nonphotosensitive

  • Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 1, Photosensitive

  • TTD1

  • Tay Syndrome

  • Trichothiodystrophy With Congenital Ichthyosis

  • Photosensitive Trichothiodystrophy

  • Ibids Syndrome

  • Ttdp

  • Ichthyosiform Erythroderma With Hair Abnormality And Mental And Growth Retardation

  • Ichthyosis, Congenital, With Trichothiodystrophy

  • Pibids Syndrome

  • Photosensitive Trichothiodystrophy 1

  • Trichothiodystrophy, Photosensitive

  • Sulfur-Deficient Brittle Hair Syndrome

  • Ttd-P

  • Ichthyosis With Brittle Hair, Intellectual Impairment, Decreased Fertility And Short Stature

  • Trichothiodystrophy Photosensitive

  • Trichothiodystrophy, Type 1

  • Tricho-Thiodystrophy Disorder

  • Trichothiodystrophy Syndromes

  • Amish Brittle Hair Brain Syndrome
Trichothiodystrophy 3, Photosensitive

  • TTD3

  • Trichothiodystrophy, Complementation Group A

  • Ttda

  • Photosensitive Trichothiodystrophy 3

  • Trichothiodystrophy Complementation Group A
Trichothiodystrophy

  • Ttd

  • Amish Brittle Hair Syndrome

  • Bids Syndrome

  • Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome

  • Ibids

  • Pibids

  • Trichothiodystrophy Syndromes
Glutaric Aciduria Iii

  • Glutaryl-Coa Oxidase Deficiency

  • Ga Iii

  • Glutaric Acidemia Type 3

  • GA3

  • Glutaric Aciduria Type 3

  • Glutaric Aciduria 3

  • Glutaric Acidemia Type Iii

  • Glutaric Aciduria Type Iii
Ciliary Dyskinesia, Primary, 6

  • Primary Ciliary Dyskinesia 6

  • CILD6

  • Ics6

  • Immotile Cilia Syndrome 6

  • Dyskinesia, Ciliary, Primary, 6
Robinow Syndrome, Autosomal Dominant 3

  • Autosomal Dominant Robinow Syndrome 3

  • DRS3

  • Robinow, Autosomal Dominant Syndrome, Type 3
Ichthyosis

  • Ichthyoses

  • Non-Syndromic Ichthyosis

  • Congenital Ichthyosis
Cerebrooculofacioskeletal Syndrome

  • Cerebro-Oculo-Facio-Skeletal Syndrome

  • Cofs Syndrome

  • Pena-Shokeir Syndrome Type 2

  • Pena Shokeir Syndrome Type 2
Uv-Sensitive Syndrome

  • Uvss

  • Uv Sensitive Syndrome

  • Ultraviolet Sensitive Syndrome
Xeroderma Pigmentosum, Variant Type

  • Xeroderma Pigmentosum

  • XPV

  • Xeroderma Pigmentosum Variant Type

  • Xeroderma Pigmentosum With Normal Dna Repair Rates

  • Photosensitivity With Defective Dna Synthesis

  • Xp

  • De Sanctis-Cacchione Syndrome

  • Desanctis-Cacchione Syndrome

  • Xeroderma Pigmentosa

  • Xerodermic Idiocy

  • Xeroderma Pigmentosum Variant

  • Xp - [Xeroderma Pigmentosum]

  • Atrophoderma Pigmentosum
Congenital Nervous System Abnormality

  • Congenital Neurologic Anomaly

  • Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08619 MPLKIP Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus MPLKIP VGNC VGNC:31579
Rattus norvegicus MPLKIP RGD RGD:1584365
Mus musculus MPLKIP MGD MGI:1913558
Felis catus MPLKIP VGNC VGNC:80626
Macaca mulatta MPLKIP VGNC VGNC:74773
Canis familiaris MPLKIP VGNC VGNC:43339
Others MPLKIP NCBI