CYP3A7 - cytochrome P450 family 3 subfamily A member 7 Gene

Also Known as CP37; CYPIIIA7; P450HLp2; P450-HFLA; P-450111A7; P-450(HFL33)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1551

About CYP3A7

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:99,705,036-99,735,196 (from NCBI)

This gene has 4 transcripts (splice variants), 678 orthologues and 3 paralogues. Biased expression in liver (RPKM 26.8), gall bladder (RPKM 5.5) and 4 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes, which participate in drug metabolism and the synthesis of Cholesterol, Steroids and Other lipids. This enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. This gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene and is represented by GeneID:100861540. [provided by RefSeq, Jan 2015]

CYP3A7 Products (1)

mRNA Protein Name
NM_000765.5 NP_000756.3 cytochrome P450 3A7

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables estrogen 16-alpha-hydroxylase activity IDA
IDA: Inferred from direct assay
14559847 GOA
enables estrogen 2-hydroxylase activity IDA
IDA: Inferred from direct assay
12865317 GOA
enables retinoic acid 4-hydroxylase activity IDA
IDA: Inferred from direct assay
11093772 GOA
enables steroid hydroxylase activity IDA
IDA: Inferred from direct assay
14559847 GOA
Biological Process GO Annotation Evidence References Source
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
12865317 GOA
involved in lipid hydroxylation IDA
IDA: Inferred from direct assay
14559847 GOA
involved in retinoic acid metabolic process IDA
IDA: Inferred from direct assay
11093772 GOA
involved in steroid metabolic process IDA
IDA: Inferred from direct assay
14559847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP3A7 Protein Structure

p450

p450: Cytochrome P450 (39 - 492)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

cytochrome P450 3A7

  • aryl hydrocarbon hydroxylase

Related Diseases

Diseases Alias
Myopathy, Centronuclear, 4

  • CNM4

  • Centronuclear Myopathy 4

  • Congenital Myopathy With Internal Nuclei And Atypical Cores

  • Centronuclear Myopathy Type 4

  • Myopathy, Centronuclear, Type 4
Neonatal Abstinence Syndrome

  • Drug Withdrawal Syndrome In Newborn
Crigler-Najjar Syndrome, Type I

  • Crigler-Najjar Syndrome

  • Crigler-Najjar Syndrome Type 1

  • Bilirubin Udp Glucuronyl Transferase Deficiency

  • Crigler Najjar Syndrome

  • Crigler Najjar Syndrome, Type 1

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency

  • Bilirubin-Ugt Deficiency

  • Hyperbilirubinemia, Crigler-Najjar Type I

  • Hblrcn1

  • Familial Nonhemolytic Unconjugated Hyperbilirubinemia

  • Hereditary Unconjugated Hyperbilirubinemia

  • Bilirubin Uridinediphosphate Glucuronosyltransferase Deficiency Type 1

  • Bilirubin-Ugt Deficiency Type 1

  • Crigler-Najjar Syndrome 1

  • CN1

  • Cn-I

  • Crigler-Najjar Syndrome Type I

  • Hereditary Unconjugated Hyperbilirubinaemia

  • Ugt Deficiency

  • Bilirubin Glucuronosyltransferase Deficiency

  • Crigler-Najjar Disease Or Syndrome

  • Deficiency Of Glucuronosyltransferase

  • Glucuronyl Transferase Deficiency

  • Glucuronyltransferase Deficiency

  • Udp Glucuronyl Transferase Deficiency

  • Cns - [Crigler-Najjar Syndrome]

  • Congenital Familial Nonhemolytic Jaundice
Dystonia 11, Myoclonic

  • Myoclonic Dystonia

  • Myoclonus-Dystonia Syndrome

  • DYT11

  • Myoclonic Dystonia 11

  • Alcohol-Responsive Dystonia

  • Myoclonus, Hereditary Essential

  • Dystonia-11, Myoclonic

  • Myoclonus-Dystonia

  • Dystonia 11

  • Hereditary Essential Myoclonus

  • Dystonia, Alcohol-Responsive

  • Dyt-Sgce

  • Dystonia, Alcohol Responsive

  • Dystonia-11

  • Dystonia, Myoclonic

  • Dystonia, Myoclonic, Type 11
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18642 CYP3cide Inhibitor 99.92% Unkown
HY-113482 1β-Hydroxydeoxycholic acid 98.0% Unkown
HY-117605 N-Desmethyl Sildenafil Inhibitor 99.60% Unkown
HY-113031 16a-Hydroxydehydroisoandrosterone 98.54% Unkown
HY-Z8033 N-Desmethyl diltiazem hydrochloride 90.0% Unkown
HY-RS03474 CYP3A7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W740175 6b-Hydroxy triamcinolone acetonide Control / Unkown