CYP51A1 - cytochrome P450 family 51 subfamily A member 1 Gene

Homo sapiens

Also known as LDM; CP51; CYP51; CYPL1; P450L1; P450-14DM

Gene ID: 1595 | Gene type: protein coding

About CYP51A1

Cytogenetic location: 7q21.2 Genomic coordinates (GRCh38): 7:92,112,153-92,134,803 (from NCBI)

This gene has 5 transcripts (splice variants), 204 orthologues and is associated with 2 phenotypes. Broad expression in liver (RPKM 53.6), testis (RPKM 45.9) and 25 other tissues.

Summary

This gene encodes a member of the Cytochrome P450 superfamily of enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and other lipids. This endoplasmic reticulum protein participates in the synthesis of Cholesterol by catalyzing the removal of the 14alpha-methyl group from lanosterol. Homologous genes are found in all three eukaryotic phyla, fungi, Plants, and Animals, suggesting that this is one of the oldest Cytochrome P450 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

CYP51A1 Products(2)

mRNA	Protein	Name
NM_000786.4	NP_000777.1	lanosterol 14-alpha demethylase isoform 1 precursor
NM_001146152.2	NP_001139624.1	lanosterol 14-alpha demethylase isoform 2

CYP51A1 Protein Structure

p450

0
100
200
300
400
509 a.a.

Protein Preferred Names

Protein Names

lanosterol 14-alpha demethylase

CYPLI

Related Diseases

Diseases

Alias

Congenital Cataract-Severe Neonatal Hepatopathy-Global Developmental Delay Syndrome

Chagas Disease

American Trypanosomiasis	Chagas' Disease
Chagas' Disease With Digestive System Involvement	Chagas' Disease With Nervous System Involvement
Chagas' Disease With Other Organ Involvement	Infection Due To Trypanosoma Cruzi
South American Trypanosomiasis	Chronic Chagas Disease With Digestive System Involvement

Antley-Bixler Syndrome

Trapezoidocephaly Synostosis Syndrome	Trapezoidocephaly-Synostosis Syndrome
Antley Bixler Syndrome	Multisynostotic Osteodysgenesis With Long Bone Fractures
Osteodysgenesis, Multisynostotic With Fractures	Antley-Bixler Syndrome, Autosomal Dominant
Antley-Bixler Syndrome Phenotype

Fusariosis

Fusarium Infection

Tinea Pedis

Athlete'S Foot	Dermatophytosis Of Foot
Ringworm Of Foot	Moccasin Foot

Tinea Unguium

Dermatophytosis Of Nail	Onychomycosis Due To Dermatophyte
Cellulitis And Abscess	Cellulitis And Abscess Of Buttock
Cellulitis And Abscess Of Face	Cellulitis And Abscess Of Finger
Cellulitis And Abscess Of Finger And Toe	Cellulitis And Abscess Of Gluteal Region
Cellulitis And Abscess Of Trunk	Cellulitis And Abscess Of Upper Arm And Forearm
Dermatophytic Onychia	Dermatophytic Onychomycosis
Onychomycosis	Ringworm Of Nails
Tinea Of Nail

Tinea Cruris

Dermatophytosis Of Groin & Perianal Area	Dermatophytosis Of Groin And Perianal Area
Dhobie Itch	Tinea Of Perianal Region

Fungal Meningitis

Meningitis, Fungal

Mycotic Meningitis

Dermatomycosis

Dermatomycoses

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Candidiasis

Systemic Candidiasis	Invasive Candidiasis
Disseminated Candidiasis	Systemic Candida Infections
Candidiasis, Invasive

Invasive Aspergillosis

Aspergillosis Invasive

Cryptococcal Meningitis

Meningitis, Cryptococcal

Meningitis Cryptococcal

Dermatophytosis

Tinea	Dermatophytosis, Unspecified
Ringworm	Infections Due To Species Of Epidermophyton, Microsporum And Trichophyton
Cutaneous Mycosis	Dermal Mycosis
Superficial Mycosis, Unspecified	Fungus Infection Of Skin
Skin Mycosis	Dermatitis Fungoid
Fungal Dermatitis	Fungal Dermatosis
Mycotic Infection Of Skin

Fungal Infectious Disease

Mycoses

Mycosis

Esophageal Candidiasis

Candidiasis Of The Esophagus	Candida Esophagitis
Candidal Esophagitis	Esophageal Moniliasis
Esophageal Thrush

Opportunistic Mycosis

Opportunistic Mycoses

Opportunistic Systemic Mycoses

Mucormycosis

Zygomycosis	Disseminated Mucormycosis
Absidia Infection	Absidia Mucoromycosis
Cunninghamella Infection	Cunninghamella Mucoromycosis
Infection By Absidia Spp	Infection By Rhizopus Spp
Mucor Infection	Mucor Mucoromycosis
Infection By Mucor Spp	Rhizopus Infection
Rhizopus Mucoromycosis	Infection By Cunninghamella Spp
Phycomycosis Nos

Pulmonary Aspergilloma

Mycobacterium Tuberculosis 1

Tuberculosis	Tuberculoma
Tuberculosis, Susceptibility To	Mycobacterium Tuberculosis, Susceptibility To, 1
Mtbs1	TB

Primary Amebic Meningoencephalitis

Pam	Naegleria Fowleri Infection
Meningoencephalitis Caused By Naegleria Fowleri	Primary Amoebic Meningoencephalitis

Tinea Capitis

Dermatophytosis Of Scalp	Scalp Ringworm
Dermatophytosis Of Scalp Or Beard	Tinea Capitis Due To Trichophyton Rubrum
Trichophyton Rubrum Tinea Capitis

Conidiobolomycosis

Infection By Conidiobolus	Rhinoentomophthoromycosis
Entomophthoromycosis Conidiobolae

Granulomatous Amebic Encephalitis

Granulomatous Amoebic Encephalitis	Acanthamoeba Encephalitis
Acanthamoeba Granulomatous Encephalitis	Granulomatous Amebic Encephalitis Due To Acanthamoeba

Eumycotic Mycetoma

Eumycetoma	Maduromycosis
Mycetoma	Madura Foot
Maduromycosis, Mycotic	Mycotic Mycetoma
Mycetoma Of Foot	Eumycotic Maduromycosis
Mycetoma Due To Fungal Infection

Trichosporonosis

Sleeping Sickness

African Trypanosomiasis	African Sleeping Sickness
Trypanosomiasis, Human East-African	Trypanosomiasis, East African
Trypanosomiasis African	Trypanosomiasis, African
Human African Trypanosomiasis

Blastomycosis

Gilchrist'S Disease	North American Blastomycosis
Blastomyces Dermatitidis Infection	Blastomycotic Infection
Infection By Blastomyces Dermatitidis	Gilchrist Disease
Chicago Disease	Chicago Disease Or Disorder
Blastomycosis, Unspecified	Blastomyces Infection

Coccidioidomycosis

Valley Fever	Primary Extrapulmonary Coccidioidomycosis
Coccidioides Immitis Infection	Coccidiosis
Coccidioides Infection	Coccidioidomycosis, Unspecified
San Joaquin Fever	California Disease
Desert Fever	Desert Rheumatism
San Joaquin Valley Fever	Enteric Coccidiosis
Primary Pulmonary Coccidioidomycosis	Acute Coccidioidomycosis
Posadas Wernicke Disease

External Ear Disease

Diseases Of External Ear	Preauricular Cyst
Preauricular Sinus And Fistula	Preauricular Sinus Or Fistula

Primary Systemic Mycosis

Congenital Hemidysplasia With Ichthyosiform Erythroderma And Limb Defects

Child Syndrome	Ichthyosiform Erythroderma, Unilateral, With Ipsilateral Malformations, Especially Absence Deformity Of Limbs
Child Nevus	Congenital Hemidysplasia With Ichthyosiform Nevus And Limbs Defects
Congenital Hemidysplasia With Ichthyosiform Nevus And Limb Defects	Ichthyosis, Child Syndrome
Child Syndrome Ichthyosis	CHILD

Otitis Externa

Swimmer'S Ear	Infective Otitis Externa
Acute Infective Otitis Externa

Vulvovaginal Candidiasis

Candidiasis Of Vulva And Vagina	Candidiasis, Vulvovaginal
Candidal Vulvovaginitis	Candidal: Cervix
Monilial Vulvovaginitis	Candidiasis Vulvovaginal

Trypanosomiasis

Cryptococcosis

Cryptococcus Neoformans Infection	Torulosis
Busse-Buschke'S Disease	Cryptococcal Infection
European Cryptococcosis	Torula
Infection By Cryptococcus Neoformans	Cryptococcosis Infection
European Blastomycosis	European Blastomycotic Infection
European Blastomycoses Infection	Torula Histolytica Infection

Visceral Leishmaniasis

Kala-Azar	Leishmaniasis, Visceral
Infection By Visceral Leishmaniasis	Leishmaniasis Visceral
Sahib Disease	Ponos
Burdwan Fever	Mard El Bicha
Sirkari Disease	Indian Visceral Leishmaniasis
Dumdum Fever	Visceral Leishmaniasis Due To Leishmania Donovani

Parasitic Protozoa Infectious Disease

Protozoan Infections	Mastigophora Infectious Disease
Sarcomastigophora Infectious Disease

Leukodystrophy

Leukodystrophies

Craniosynostosis

Premature Closure Of Cranial Sutures	Craniostenosis
Craniosynostosis Syndrome	Cso
Craniosynostoses	Congenital Ossification Of Cranial Sutures
Congenital Ossification Of Sutures Of Skull	Craniostosis
Imperfect Fusion Of Skull	Congenital Imperfect Closure Skull
Imperfect Closure Skull	Premature Closure Cranium Sutures
Deficiency Of Craniofacial Axis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N7266	Obtusifoliol	Inhibitor	99.86%	Unkown
HY-116568	Prothioconazole	Inhibitor	/	Unkown
HY-144643	CYP51/HDAC-IN-1	Inhibitor	/	Unkown
HY-149617	CYP51/PD-L1-IN-4	Inhibitor	/	Unkown
HY-156149	CYP51/PD-L1-IN-1	Inhibitor	/	Unkown
HY-156150	CYP51/PD-L1-IN-2	Inhibitor	/	Unkown
HY-156151	CYP51/PD-L1-IN-3	Inhibitor	/	Unkown
HY-RS03486	CYP51A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CYP51A1	VGNC	VGNC:50376
Felis catus	CYP51A1	VGNC	VGNC:103342
Mus musculus	CYP51A1	MGD	MGI:106040
Rattus norvegicus	CYP51A1	RGD	RGD:2481
Bos taurus	CYP51A1	VGNC	VGNC:110275
Macaca mulatta	CYP51A1	VGNC	VGNC:103628