DACH1 - dachshund family transcription factor 1 Gene

Also Known as DACH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1602

About DACH1

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:71,437,966-71,867,204 (from NCBI)

This gene has 4 transcripts (splice variants), 199 orthologues and 1 paralogue. Broad expression in adrenal (RPKM 3.2), gall bladder (RPKM 2.4) and 21 other tissues.

Summary

This gene encodes a chromatin-associated protein that associates with Other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic Cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

DACH1 Products (4)

mRNA	Protein	Name
NM_001366712.1	NP_001353641.1	dachshund homolog 1 isoform d
NM_004392.7	NP_004383.4	dachshund homolog 1 isoform c
NM_080759.6	NP_542937.3	dachshund homolog 1 isoform a
NM_080760.6	NP_542938.3	dachshund homolog 1 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	20956529	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956529	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20956529	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14525983	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA biosynthetic process	IDA IDA: Inferred from direct assay	16980615	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21750150	GOA
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	20956529	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20956529	GOA
involved in negative regulation of transcription by competitive promoter binding	IMP IMP: Inferred from mutant phenotype	20956529	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DACH1 Protein Structure

Ski_Sno

0
200
400
600
708 a.a.

Protein Preferred Names	Protein Names
dachshund homolog 1	dac homolog

DACH1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DACH1	Q9UI36	NAGK	Homo sapiens	Q9UJ70	Y2H	21516116
Intra	DACH1	Q9UI36	NAGK	Homo sapiens	Q9UJ70	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colobomatous Microphthalmia	Anophthalmia-Microphthalmia Syndrome Mac Microphthalmia With Colobomatous Cyst Microphthalmia-Anophthalmia-Coloboma Syndrome Microphthalmia-Anophthalmia-Coloboma Microphthalmia And Mental Deficiency
Granular Cell Carcinoma	Granular Cell Cancer Granular Cell Adenocarcinoma
Supraglottis Neoplasm	Neoplasm Of Supraglottis Supraglottic Tumor
Deafness, Autosomal Dominant 10	DFNA10 Autosomal Dominant Nonsyndromic Deafness 10 Autosomal Dominant Deafness 10 Deafness, Autosomal Dominant, 10 Non-Syndromic Neurosensory Deafness Autosomal Dominant Type 10 Non-Syndromic Sensorineural Deafness Autosomal Dominant Type 10 Deafness, Autosomal Dominant, Type 10
Syndromic X-Linked Intellectual Disability Snyder Type	Snyder-Robinson Syndrome Mental Retardation, X-Linked, Snyder-Robinson Type Spermine Synthase Deficiency Srs Snyder-Robinson Mental Retardation Syndrome X-Linked Intellectual Disability Snyder-Robinson Type Mental Retardation, X-Linked, Syndromic, Snyder-Robinson Type Snyder-Robinson X-Linked Mental Retardation Syndrome
Branchiootorenal Syndrome	Branchio-Oto-Renal Syndrome Bor Syndrome Branchiootorenal Dysplasia Melnick-Fraser Syndrome Branchiootorenal Spectrum Disorders Branchio-Otorenal Dysplasia Branchio Oto Renal Syndrome Branchiootorenal/Branchiootic Syndrome Bo Syndrome Bor Bos Branchio-Otorenal Syndrome Branchiootic Syndrome Branchiootorenal Syndrome Branchiootic Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03513	DACH1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DACH1	MGD	MGI:1277991
Rattus norvegicus	DACH1	RGD	RGD:1592073
Bos taurus	DACH1	VGNC	VGNC:106704
Macaca mulatta	DACH1	VGNC	VGNC:71725
Others	DACH1	NCBI