DLX4 - distal-less homeobox 4 Gene

Homo sapiens

Also known as BP1; DLX7; DLX8; DLX9; OFC15

Gene ID: 1748 | Gene type: protein coding

About DLX4

Cytogenetic location: 17q21.33 Genomic coordinates (GRCh38): 17:49,968,572-49,974,959 (from NCBI)

This gene has 6 transcripts (splice variants), 453 orthologues, 9 paralogues and is associated with 2 phenotypes. Biased expression in placenta (RPKM 1.9), skin (RPKM 0.3) and 3 other tissues.

Summary

Many vertebrate homeo box-containing genes have been identified on the basis of their sequence similarity with Drosophila developmental genes. Members of the Dlx gene family contain a homeobox that is related to that of Distal-less (Dll), a gene expressed in the head and limbs of the developing fruit fly. The Distal-less (Dlx) family of genes comprises at least 6 different members, DLX1-DLX6. The DLX proteins are postulated to play a role in forebrain and craniofacial development. Three transcript variants have been described for this gene, however, the full length nature of one variant has not been described. Studies of the two splice variants revealed that one encoded isoform functions as a repressor of the beta-globin gene while the other isoform lacks that function. [provided by RefSeq, Jul 2008]

DLX4 Products(2)

mRNA	Protein	Name
NM_001934.4	NP_001925.2	homeobox protein DLX-4 isoform b
NM_138281.3	NP_612138.1	homeobox protein DLX-4 isoform a

DLX4 Protein Structure

Homeobox

0
100
200
240 a.a.

Protein Preferred Names

Protein Names

homeobox protein DLX-4

beta protein 1

Related Diseases

Diseases

Alias

Orofacial Cleft 15

OFC15

Non-Syndromic Orofacial Cleft 15

Cleft Lip/Palate

Cleft Lip And Palate	Alveolar Cleft Lip And Palate
Cleft Lip-Alveolus-Palate Syndrome	Flp

Trichodentoosseous Syndrome

Tricho-Dento-Osseous Syndrome	Tdo Syndrome
Trichodontoosseous Syndrome	TDO
Enamel Hypoplasia And Hypocalcification With Associated Strikingly Curly Hair

Cleft Lip

Cheiloschisis	Labium Leporinum
Cleft Lip, Unilateral, Complete	Complete Unilateral Cleft Lip
Hare Lip	Congenital Fissure Of Lip
Isolated Cleft Lip	Cleft Lip Without Cleft Palate
Cleft Lip Without Cleft Palate, Unilateral	Isolated Cleft Lip, Unilateral
Cleft Lip Without Cleft Palate, Bilateral	Isolated Cleft Lip, Bilateral

Orofacial Cleft

Cleft, Orofacial

Amelogenesis Imperfecta, Type Iv

AI4	Aihht
Amelogenesis Imperfecta Type 4	Hypomaturation-Hypoplastic Amelogenesis Imperfecta With Taurodontism
Amelogenesis Imperfecta, Hypomaturation-Hypoplastic Type, With Taurodontism	Amelogenesis Imperfecta Hypomaturation-Hypoplastic Type With Taurodontism
Amelogenesis Imperfecta 4	Ait
Amelogenesis Imperfecta 2 Hypocalcification Type	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iv	Amelogenesis Imperfecta With Taurodontism

Choriocarcinoma

Chorioepithelioma

Blepharocheilodontic Syndrome 1

Blepharocheilodontic Syndrome	Bcd Syndrome
Elschnig Syndrome	Clefting, Ectropion, And Conical Teeth
Lagophthalmia With Bilateral Cleft Lip And Palate	Blepharo-Cheilo-Odontic Syndrome
Bcds	Ectropion, Inferior, With Cleft Lip And/Or Palate
Blepharo-Cheilo-Dontic Syndrome	BCDS1
Ectropion Inferior Cleft Lip And Or Palate	Clefting-Ectropion-Conical Teeth Syndrome
Ectropion Inferior-Cleft Lip And/Or Palate Syndrome	Lagophthalmia-Cleft Lip And Palate Syndrome
Blepharocheilodontic Syndrome, Type 1

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Lagophthalmos

Defective Lid Closure

Poor Closure Eyelids

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03815	DLX4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DLX4	RGD	RGD:1308744
Bos taurus	DLX4	VGNC	VGNC:28100
Mus musculus	DLX4	MGD	MGI:94904
Felis catus	DLX4	VGNC	VGNC:61523
Macaca mulatta	DLX4	VGNC	VGNC:99142
Canis familiaris	DLX4	VGNC	VGNC:53207