EFNA4 - ephrin A4 Gene

Also Known as EFL4; EPLG4; LERK4; LERK-4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 1945

About EFNA4

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:155,063,740-155,069,553 (from NCBI)

This gene has 3 transcripts (splice variants), 149 orthologues and 7 paralogues. Ubiquitous expression in skin (RPKM 7.7), colon (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes a member of the ephrin (EPH) family. The Ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, Ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin that has been implicated in proliferation and metastasis of several types of cancers. [provided by RefSeq, May 2022]

EFNA4 Products (4)

mRNA Protein Name
NM_001406810.1 NP_001393739.1 ephrin-A4 isoform d
NM_005227.3 NP_005218.1 ephrin-A4 isoform a precursor
NM_182689.2 NP_872631.1 ephrin-A4 isoform b precursor
NM_182690.3 NP_872632.2 ephrin-A4 isoform c precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables ephrin receptor binding IPI
IPI: Inferred from physical interaction
11519828 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15777695 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EFNA4 Protein Structure

Ephrin

Ephrin: Ephrin (25 - 155)

  • 0
  • 100
  • 201 a.a.
Protein Preferred Names Protein Names

ephrin-A4

  • eph-related receptor tyrosine kinase ligand 4

EFNA4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EFNA4 P52798 TMEM147 Homo sapiens Q9BVK8
Validated Y2H
32296183
Intra
EFNA4 P52798 EPHA4 Homo sapiens P54764
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant EFNA4 Proteins

Cat. No. Product Name Accession Purity
HY-P70376 Ephrin-A4/EFNA4 Protein, Human (HEK293, His) P52798 (L26-G171) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P73010 Ephrin-A4/EFNA4 Protein, Human (HEK293, Fc) P52798 (L26-G171) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Craniofrontonasal Syndrome

  • Craniofrontonasal Dysplasia

  • CFNS

  • Cfnd

  • Craniofrontonasal Dysostosis

  • Craniofrontonasal Dystosis

  • Dysplasia, Craniofrontonasal
Craniosynostosis

  • Premature Closure Of Cranial Sutures

  • Craniostenosis

  • Craniosynostosis Syndrome

  • Cso

  • Craniosynostoses

  • Congenital Ossification Of Cranial Sutures

  • Congenital Ossification Of Sutures Of Skull

  • Craniostosis

  • Imperfect Fusion Of Skull

  • Congenital Imperfect Closure Skull

  • Imperfect Closure Skull

  • Premature Closure Cranium Sutures

  • Deficiency Of Craniofacial Axis
Muenke Syndrome

  • Muenke Nonsyndromic Coronal Craniosynostosis

  • Fgfr3-Related Craniosynostosis

  • Fgfr3-Associated Coronal Synostosis

  • Coronal Craniosynostosis

  • MNKES

  • Syndrome Of Coronal Craniosynostosis

  • MNKS

  • Fgfr3-Related Isolated Coronal Synostosis

  • Muenke Non-Syndromic Coronal Craniosynostosis
Saethre-Chotzen Syndrome

  • SCS

  • Acs3

  • Acs Iii

  • Chotzen Syndrome

  • Acrocephaly, Skull Asymmetry, And Mild Syndactyly

  • Acrocephalosyndactyly Type 3

  • Acrocephalosyndactyly, Type Iii

  • Acrocephalosyndactyly Type Iii

  • Saethre-Chotzen Syndrome With Or Without Eyelid Anomalies

  • Auralcephalosyndactyly

  • Acs 3

  • Acrocephalo-Syndactyly, Type 3

  • Blepharophimosis,Epicanthus Inversus, And Ptosis 3

  • Aural Cephalosyndactyly

  • Kurczynski-Casperson Syndrome

  • Acrocephalosyndactyly Iii

  • Dysostosis Craniofacialis With Hypertelorism

  • Saethre-Chotzen Syndrome, With/Without Eyelid Anomalies

  • Sakati Syndrome
Apert Syndrome

  • Acrocephalosyndactyly Type I

  • Acs1

  • Acrocephalosyndactylia

  • Acrocephalosyndactyly

  • Acs I

  • Apert-Crouzon Disease

  • Acrocephalosyndactyly Type 1

  • Acrocephalosyndactyly, Type I

  • Acs 1

  • Acrocephalo-Syndactyly Type 1

  • Syndactylic Oxycephaly

  • Apert'S Syndrome

  • Type I Acrocephalosyndactyly

  • APRS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-111965 PF-06647263 Inducer / Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04195 EFNA4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18174 Efna4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24648 Efna4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991109 Anti-EFNA4 Antibody Inhibitor 99.60% Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EFNA4 VGNC VGNC:107870
Rattus norvegicus EFNA4 RGD RGD:1307808
Canis familiaris EFNA4 VGNC VGNC:40227
Mus musculus EFNA4 MGD MGI:106643
Bos taurus EFNA4 VGNC VGNC:28357
Others EFNA4 NCBI