FGF12 - fibroblast growth factor 12 Gene

Homo sapiens

Also known as FHF1; DEE47; EIEE47; FGF12B

Gene ID: 2257 | Gene type: protein coding

About FGF12

Cytogenetic location: 3q28-q29 Genomic coordinates (GRCh38): 3:192,139,390-192,727,541 (from NCBI)

This gene has 14 transcripts (splice variants), 281 orthologues, 21 paralogues and is associated with 3 phenotypes. Biased expression in heart (RPKM 20.8), brain (RPKM 14.1) and 2 other tissues.

Summary

The protein encoded by this gene is a member of the Fibroblast Growth Factor (FGF) family. FGF Family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. This growth factor lacks the N-terminal signal sequence present in most of the FGF Family members, but it contains clusters of basic residues that have been demonstrated to act as a nuclear localization signal. When transfected into mammalian cells, this protein accumulated in the nucleus, but was not secreted. The specific function of this gene has not yet been determined. [provided by RefSeq, Dec 2019]

FGF12 Products(5)

mRNA	Protein	Name
NM_001377292.1	NP_001364221.1	fibroblast growth factor 12 isoform 3
NM_001377293.1	NP_001364222.1	fibroblast growth factor 12 isoform 4
NM_001377294.1	NP_001364223.1	fibroblast growth factor 12 isoform 4
NM_004113.6	NP_004104.3	fibroblast growth factor 12 isoform 2
NM_021032.5	NP_066360.1	fibroblast growth factor 12 isoform 1

FGF12 Protein Structure

FGF

0
100
200
243 a.a.

Protein Preferred Names

Protein Names

fibroblast growth factor 12

fibroblast growth factor 12B

Recombinant FGF12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7343	FGF-12 Protein, Human (177 a.a)	P61328 (E67-T243)	≥95%
HY-P71959	FGF-12 Protein, Human (181a.a)	P61328-2 (M1-T181)	≥95%
HY-P72654	FGF-12 Protein, Human	P61328-2 (M1-T181)	≥95%
HY-P700056AF	Animal-Free FGF-12 Protein, Human (His)	P61328-2 (M1-T181)	≥95%
HY-P71959A	FGF-12 Protein, Human (181a.a, His)	P61328-2 (M1-T181)	≥95%

Related Diseases

Diseases

Alias

Developmental And Epileptic Encephalopathy 47

DEE47	Epileptic Encephalopathy, Early Infantile, 47
Eiee47	Developmental And Epileptic Encephalopathy, 47
Early Infantile Epileptic Encephalopathy 47

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Breast Juvenile Papillomatosis

Juvenile Papillomatosis Of The Breast

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Myasthenic Syndrome, Congenital, 22

CMS22	Prepl Deficiency
Congenital Myasthenic Syndrome 22

Deafness, Autosomal Dominant 44

DFNA44	Autosomal Dominant Nonsyndromic Deafness 44
Autosomal Dominant Deafness 44	Deafness, Autosomal Dominant, 44
Deafness, Autosomal Dominant, Type 44

Developmental And Epileptic Encephalopathy 94

Epileptic Encephalopathy, Childhood-Onset	Eeoc
DEE94	Childhood Onset Epileptic Encephalopathy
Encephalopathy, Epileptic, Childhood-Onset

Cleft Palate, Isolated

Cleft Palate	Isolated Cleft Palate
CPI	Cp
Palatoschisis	Cleft Palate Isolated
Uranostaphyloschisis	Congenital Fissure Of Palate
Cleft Of Secondary Palate

Autism Spectrum Disorder

Asd	Autism Spectrum Disorders
Autistic Continuum	Pervasive Developmental Disorder
Pervasive Development Disorder	Autistic Behavior
Autistic Disorder	Autistic
Autistic Disorder Of Childhood Onset	Infantile Autism
Childhood Autism	Kanner Syndrome
Pervasive Developmental Delay Nos	Pervasive Developmental Disorder, Not Otherwise Specified

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Burst-Suppression	Early Infantile Epileptic Encephalopathy With Suppression Bursts
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04889	FGF12 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	FGF12	VGNC	VGNC:72644
Mus musculus	FGF12	MGD	MGI:109183
Canis familiaris	FGF12	VGNC	VGNC:40841
Bos taurus	FGF12	VGNC	VGNC:53568
Felis catus	FGF12	VGNC	VGNC:62246
Rattus norvegicus	FGF12	RGD	RGD:620163
Others	FGF12	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.