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ZNF460 - zinc finger protein 460 Gene

Also Known as HZF8; ZNF272

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10794

About ZNF460

Cytogenetic location: 19q13.43 Genomic coordinates (GRCh38): 19:57,279,982-57,294,069 (from NCBI)

This gene has 3 transcripts (splice variants), 139 orthologues and 174 paralogues. Ubiquitous expression in adrenal (RPKM 1.2), bone marrow (RPKM 1.1) and 25 other tissues.

Summary

Zinc finger proteins, such as ZNF272, interact with nucleic acids and have diverse functions. The zinc finger domain is a conserved amino acid sequence motif containing 2 specifically positioned cysteines and 2 histidines that are involved in coordinating zinc. Kruppel-related proteins form 1 family of zinc finger proteins. See ZFP93 (MIM 604749) for additional information on zinc finger proteins.[supplied by OMIM, May 2004]

ZNF460 Products (2)

mRNA	Protein	Name
NM_001330622.2	NP_001317551.1	zinc finger protein 460 isoform 2
NM_006635.4	NP_006626.3	zinc finger protein 460 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF460 Protein Structure

KRAB

zf-H2C2_2

0
100
200
300
400
500
562 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 460	zinc finger protein 272

ZNF460 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNF460	Q14592	ZNF250	Homo sapiens	P15622-3	Y2H Array	25416956
Intra	ZNF460	Q14592	DMWD	Homo sapiens	G5E9A7	Validated Y2H	32814053
Intra	ZNF460	Q14592	DMWD	Homo sapiens	G5E9A7	Y2H Pooling	32814053
Intra	ZNF460	Q14592	DMWD	Homo sapiens	G5E9A7	Y2H Array	32814053
Intra	ZNF460	Q14592	ZNF330	Homo sapiens	Q9Y3S2	Validated Y2H	32296183
Intra	ZNF460	Q14592	SPRED1	Homo sapiens	Q7Z699	Y2H Array	32814053
Intra	ZNF460	Q14592	SPRED1	Homo sapiens	Q7Z699	Y2H Pooling	32814053
Intra	ZNF460	Q14592	SPRED1	Homo sapiens	Q7Z699	Validated Y2H	32814053
Intra	ZNF460	Q14592	FGF12	Homo sapiens	P61328	Validated Y2H	25416956
Intra	ZNF460	Q14592	FGF12	Homo sapiens	P61328	Y2H Array	25416956
Intra	ZNF460	Q14592	TRIM41	Homo sapiens	Q8WV44	Anti Tag CoIP	33961781
Intra	ZNF460	Q14592	TRIM41	Homo sapiens	Q8WV44	Validated Y2H	32296183
Intra	ZNF460	Q14592	DEUP1	Homo sapiens	Q05D60	Validated Y2H	25416956
Intra	ZNF460	Q14592	DEUP1	Homo sapiens	Q05D60	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cystathioninuria	Cystathionase Deficiency Gamma-Cystathionase Deficiency Cystathione Gamma-Lyase Deficiency Syndrome Cystathionine Gamma-Lyase Deficiency Syndrome CSTNU
Colon Lymphoma	Colonic Lymphoma Lymphoma Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16143	ZNF460 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown