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DCTD - dCMP deaminase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1635

About DCTD

Cytogenetic location: 4q35.1 Genomic coordinates (GRCh38): 4:182,890,091-182,917,611 (from NCBI)

This gene has 17 transcripts (splice variants), 245 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 37.0), adrenal (RPKM 19.8) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the deamination of dCMP to dUMP, the nucleotide substrate for Thymidylate Synthase. The encoded protein is allosterically activated by dCTP and inhibited by dTTP, and is found as a homohexamer. This protein uses zinc as a cofactor for its activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

DCTD Products (9)

mRNA	Protein	Name
NM_001012732.2	NP_001012750.1	deoxycytidylate deaminase isoform a
NM_001351743.2	NP_001338672.1	deoxycytidylate deaminase isoform b
NM_001351744.2	NP_001338673.1	deoxycytidylate deaminase isoform b
NM_001351745.2	NP_001338674.1	deoxycytidylate deaminase isoform b
NM_001351747.2	NP_001338676.1	deoxycytidylate deaminase isoform b
NM_001351748.2	NP_001338677.1	deoxycytidylate deaminase isoform b
NM_001351750.2	NP_001338679.1	deoxycytidylate deaminase isoform b
NM_001351753.2	NP_001338682.1	deoxycytidylate deaminase isoform b
NM_001921.3	NP_001912.2	deoxycytidylate deaminase isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables deoxyribonucleoside 5'-monophosphate N-glycosidase activity	IDA IDA: Inferred from direct assay	33833118	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in nucleoside salvage	IMP IMP: Inferred from mutant phenotype	33833118	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DCTD Protein Structure

dCMP_cyt_deam_1

0
100
178 a.a.

Protein Preferred Names	Protein Names
deoxycytidylate deaminase

DCTD Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DCTD	P32321	UBE2I	Homo sapiens	Q7KZS0	Validated Y2H	32296183
Intra	DCTD	P32321	UBE2I	Homo sapiens	Q7KZS0	Y2H Prey Pooling	32296183
Intra	DCTD	P32321	UBE2I	Homo sapiens	Q7KZS0	Y2H Array	32296183
Intra	DCTD	P32321	MALSU1	Homo sapiens	Q96EH3	Y2H Prey Pooling	25416956
Intra	DCTD	P32321	MALSU1	Homo sapiens	Q96EH3	Validated Y2H	25416956
Intra	DCTD	P32321	MALSU1	Homo sapiens	Q96EH3	Validated Y2H	32296183
Intra	DCTD	P32321	TXN2	Homo sapiens	Q99757	Y2H Prey Pooling	25416956
Intra	DCTD	P32321	TXN2	Homo sapiens	Q99757	Validated Y2H	25416956
Intra	DCTD	P32321	TXN2	Homo sapiens	Q99757	Y2H Array	25416956
Intra	DCTD	P32321	FGF12	Homo sapiens	P61328	Y2H Array	25416956
Intra	DCTD	P32321	SDCBP	Homo sapiens	O00560	Y2H Prey Pooling	25416956
Intra	DCTD	P32321	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	29892012
Intra	DCTD	P32321	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	25416956
Intra	DCTD	P32321	GORASP2	Homo sapiens	Q9H8Y8	Y2H Prey Pooling	25416956
Intra	DCTD	P32321	GORASP2	Homo sapiens	Q9H8Y8	Validated Y2H	32296183
Intra	DCTD	P32321	GORASP2	Homo sapiens	Q9H8Y8	Y2H Array	25416956
Intra	DCTD	P32321	DCTD	Homo sapiens	P32321	Y2H	21988832
Intra	DCTD	P32321	DCTD	Homo sapiens	P32321	Y2H Prey Pooling	32296183
Intra	DCTD	P32321	DCTD	Homo sapiens	P32321	Validated Y2H	32296183
Intra	DCTD	P32321	DCTD	Homo sapiens	P32321	Y2H Array	32296183
Intra	DCTD	P32321	DCTD	Homo sapiens	P32321	Y2H Pooling	16189514
Intra	DCTD	P32321	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Granulomatosis With Polyangiitis	GPA Wegener Granulomatosis Wegener Granulomatosis, Formerly Midline Granulomatosis Wg, Formerly Necrotizing Respiratory Granulomatosis Wg Wegeners Granulomatosis Pauci-Immune Glomerulonephritis Associated With Granulomatosis With Polyangiitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03592	DCTD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DCTD	VGNC	VGNC:71750
Canis familiaris	DCTD	VGNC	VGNC:39815
Bos taurus	DCTD	VGNC	VGNC:27927
Mus musculus	DCTD	MGD	MGI:2444529
Felis catus	DCTD	VGNC	VGNC:107325
Rattus norvegicus	DCTD	RGD	RGD:1359671
Others	DCTD	NCBI