ZNF365 - zinc finger protein 365 Gene

Also Known as UAN; Su48; ZNF365D

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22891

About ZNF365

Cytogenetic location: 10q21.2 Genomic coordinates (GRCh38): 10:62,374,369-62,480,285 (from NCBI)

This gene has 4 transcripts (splice variants), 193 orthologues, 1 paralogue and is associated with 3 phenotypes. Biased expression in brain (RPKM 9.2), esophagus (RPKM 2.1) and 3 other tissues.

Summary

This gene encodes a Zinc Finger Protein that may play a role in the repair of DNA damage and maintenance of genome stability. The N-terminal C2H2 zinc finger motif is required to form a protein complex with PARP1 and MRE11, which are known to be involved in the restart of stalled DNA replication forks. A mutation in this gene may be associated with breast Cancer susceptibility. [provided by RefSeq, Mar 2020]

ZNF365 Products (2)

mRNA Protein Name
NM_014951.3 NP_055766.2 protein ZNF365 isoform A
NM_199450.3 NP_955522.1 protein ZNF365 isoform B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
16617106 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16682949 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
16617106 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within gamma-tubulin complex localization IMP
IMP: Inferred from mutant phenotype
16617106 GOA
acts upstream of or within mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
16617106 GOA
involved in negative regulation of neuron projection development IDA
IDA: Inferred from direct assay
17389905 GOA
involved in regulation of DNA strand resection involved in replication fork processing IMP
IMP: Inferred from mutant phenotype
23966166 GOA
involved in regulation of double-strand break repair via homologous recombination IMP
IMP: Inferred from mutant phenotype
23966166 GOA
involved in telomere maintenance IMP
IMP: Inferred from mutant phenotype
23776040 GOA
Cellular Component GO Annotation Evidence References Source
located in centrosome IDA
IDA: Inferred from direct assay
16617106 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein ZNF365

  • DISC1-binding zinc-finger protein

ZNF365 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZNF365 Q70YC5 NDE1 Homo sapiens Q9NXR1
Y2H
16682949
Intra
ZNF365 Q70YC5 NDE1 Homo sapiens Q9NXR1
IF
16682949
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nephrolithiasis, Uric Acid

  • Nephrolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Urolithiasis

  • Uric Acid Nephrolithiasis

  • UAN

  • Acute Urate Nephropathy

  • Urolithiasis, Uric Acid

  • Urolithiasis, Uric Acid, Susceptibility To

  • Uric Acid Renal Calculus
Narcolepsy 2

  • Narcolepsy 2, Susceptibility To

  • Narcolepsy Without Cataplexy

  • NRCLP2

  • Narcolepsy Type 2

  • Narcolepsy Without Cataplexy And Hypocretin Deficiency
Narcolepsy 1

  • NRCLP1

  • Narcoleptic Syndrome 1

  • Gelineau Disease

  • Narcolepsy-Cataplexy

  • Narcolepsy-Cataplexy Syndrome

  • Narcolepsy, Type 1

  • Narcolepsy Type 1

  • Cataplexy

  • Gélineau'S Syndrome

  • Narcolepsy With Cataplexy And/Or Hypocretin Deficiency
Mammographic Density
Nephrolithiasis

  • Kidney Stones

  • Stone - Kidney/Ureter

  • Kidney Calculi
Urolithiasis
Narcolepsy

  • Paroxysmal Sleep

  • Gelineau Syndrome

  • Narcoleptic Syndrome

  • Narcolepsy-Cataplexy Syndrome

  • Cataplexy And Narcolepsy

  • Narcolepsy, Without Cataplexy

  • Gelineau'S Syndrome

  • Narcolepsy With Or Without Cataplexy

  • Narcolepsy Nos
Vogt-Koyanagi-Harada Disease

  • Uveomeningoencephalitic Syndrome

  • Uveomenigitic Syndrome

  • Vogt-Koyanagi-Harada Syndrome

  • Harada'S Disease

  • Vogt-Koyanagi Syndrome

  • Vkh Disease

  • Vkh Syndrome

  • Vkh
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16131 ZNF365 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ZNF365 VGNC VGNC:55088
Macaca mulatta ZNF365 VGNC VGNC:106123
Canis familiaris ZNF365 VGNC VGNC:48710
Mus musculus ZNF365 MGD MGI:2143676
Felis catus ZNF365 VGNC VGNC:67295