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FOXD4 - forkhead box D4 Gene

Also Known as FKHL9; FOXD4A; FREAC5; FREAC-5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2298

About FOXD4

Cytogenetic location: 9p24.3 Genomic coordinates (GRCh38): 9:116,231-118,417 (from NCBI)

This gene has 1 transcript (splice variant), 58 orthologues and 42 paralogues.

Summary

This gene encodes a member of the forkhead/winged helix-box (FOX) family of transcription factors. FOX transcription factors play critical roles in the regulation of multiple processes including metabolism, cell proliferation and gene expression during ontogenesis. Mutations in this gene are associated with a complex phenotype consisting of dilated cardiomyopathy, obsessive-compulsive disorders, and suicidality. [provided by RefSeq, Mar 2012]

FOXD4 Products (1)

mRNA	Protein	Name
NM_207305.5	NP_997188.2	forkhead box protein D4

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Verweise	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FOXD4 Protein Structure

Forkhead

0
100
200
300
400
439 a.a.

Protein Preferred Names	Protein Names
forkhead box protein D4	forkhead, Drosophila, homolog-like 9

FOXD4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	FOXD4	Q12950	KRTAP12-2	Homo sapiens	P59991	Y2H Prey Pooling	32296183
Intra	FOXD4	Q12950	KRTAP12-2	Homo sapiens	P59991	Y2H Array	32296183
Intra	FOXD4	Q12950	KRTAP10-6	Homo sapiens	P60371	Y2H Prey Pooling	32296183
Intra	FOXD4	Q12950	KRTAP10-6	Homo sapiens	P60371	Y2H Array	32296183
Intra	FOXD4	Q12950	AKAP8L	Homo sapiens	Q9ULX6	Y2H Prey Pooling	32296183
Intra	FOXD4	Q12950	AKAP8L	Homo sapiens	Q9ULX6	Y2H Array	32296183
Intra	FOXD4	Q12950	AKAP8L	Homo sapiens	Q9ULX6	Validated Y2H	32296183
Intra	FOXD4	Q12950	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	FOXD4	Q12950	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	FOXD4	Q12950	MDFI	Homo sapiens	Q99750	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 9p Deletion Syndrome	Monosomy 9p Monosomy 9p Syndrome Alfi Syndrome 9p Syndrome Chromosome 9p Deletion 9p Deletion 9p Monosomy Deletion 9p Partial Monosomy 9p 9p Deletion Syndrome 9p- Syndrome Alfi'S Syndrome Chromosome 9, Partial Trisomy 9p
Intellectual Developmental Disorder, Autosomal Dominant 2	MRD2 Autosomal Dominant Non-Syndromic Intellectual Disability 2 Autosomal Dominant Intellectual Developmental Disorder 2 Mental Retardation, Autosomal Dominant 2
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy
Ritscher-Schinzel Syndrome	3c Syndrome Ccc Dysplasia Craniocerebellocardiac Dysplasia Cranio-Cerebello-Cardiac Dysplasia
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS05046	FOXD4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	FOXD4	MGD	MGI:1347467
Rattus norvegicus	FOXD4	RGD	RGD:621716