ZHX3 - zinc fingers and homeoboxes 3 Gene

Also Known as TIX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23051

About ZHX3

Cytogenetic location: 20q12 Genomic coordinates (GRCh38): 20:41,178,455-41,317,731 (from NCBI)

This gene has 21 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 8.0), brain (RPKM 7.6) and 25 other tissues.

Summary

This gene encodes a member of the zinc fingers and homeoboxes (ZHX) gene family. The encoded protein contains two C2H2-type zinc fingers and five homeodomains and forms a dimer with itself or with zinc fingers and homeoboxes family member 1. In the nucleus, the dimerized protein interacts with the A subunit of the ubiquitous transcription factor nuclear factor-Y and may function as a transcriptional repressor. [provided by RefSeq, Jul 2008]

ZHX3 Products (12)

mRNA	Protein	Name
NM_001384315.1	NP_001371244.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384316.1	NP_001371245.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384317.1	NP_001371246.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384318.1	NP_001371247.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384319.1	NP_001371248.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384320.1	NP_001371249.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384321.1	NP_001371250.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384322.1	NP_001371251.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384323.1	NP_001371252.1	zinc fingers and homeoboxes protein 3 isoform a
NM_001384324.1	NP_001371253.1	zinc fingers and homeoboxes protein 3 isoform b
NM_001384325.1	NP_001371254.1	zinc fingers and homeoboxes protein 3 isoform c
NM_015035.4	NP_055850.1	zinc fingers and homeoboxes protein 3 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	12659632	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12659632	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	12659632	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12659632	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12659632	GOA
involved in positive regulation of osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	21174497	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	12659632	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZHX3 Protein Structure

Homeobox

Homez

0
200
400
600
800
956 a.a.

Protein Preferred Names	Protein Names
zinc fingers and homeoboxes protein 3	triple homeobox 1

ZHX3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZHX3	Q9H4I2	NLK	Homo sapiens	Q9UBE8	Y2H	21516116
Intra	ZHX3	Q9H4I2	NLK	Homo sapiens	Q9UBE8	Y2H Prey Pooling	25416956
Intra	ZHX3	Q9H4I2	NLK	Homo sapiens	Q9UBE8	Validated Y2H	25416956
Intra	ZHX3	Q9H4I2	NLK	Homo sapiens	Q9UBE8	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16072	ZHX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZHX3	VGNC	VGNC:67245
Canis familiaris	ZHX3	VGNC	VGNC:48633
Macaca mulatta	ZHX3	VGNC	VGNC:78991
Mus musculus	ZHX3	MGD	MGI:2444772
Rattus norvegicus	ZHX3	RGD	RGD:631431
Bos taurus	ZHX3	VGNC	VGNC:37184