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SIN3B - SIN3 transcription regulator family member B Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23309

About SIN3B

Cytogenetic location: 19p13.11 Genomic coordinates (GRCh38): 19:16,829,398-16,880,349 (from NCBI)

This gene has 12 transcripts (splice variants), 206 orthologues, 1 paralogue and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 19.2), endometrium (RPKM 17.1) and 25 other tissues.

Summary

Predicted to enable transcription corepressor activity. Predicted to be involved in histone deacetylation; negative regulation of transcription by RNA polymerase II; and striated muscle tissue development. Predicted to be located in nucleus. Predicted to be part of Sin3 complex. Predicted to be active in chromatin. [provided by Alliance of Genome Resources, Apr 2022]

SIN3B Products (3)

mRNA	Protein	Name
NM_001297595.2	NP_001284524.1	paired amphipathic helix protein Sin3b isoform 2
NM_001297597.2	NP_001284526.1	paired amphipathic helix protein Sin3b isoform 3
NM_015260.4	NP_056075.1	paired amphipathic helix protein Sin3b isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12670868	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIN3B Protein Structure

PAH

Sin3_corepress

0
200
400
600
800
1000
1162 a.a.

Protein Preferred Names	Protein Names
paired amphipathic helix protein Sin3b	SIN3 homolog B, transcriptional regulator

SIN3B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SIN3B	O75182	MYC	Homo sapiens	P01106	CH-IP	24951594
Intra	SIN3B	O75182	MYC	Homo sapiens	P01106	Confocal	24951594
Intra	SIN3B	O75182	MYC	Homo sapiens	P01106	Anti Bait CoIP	24951594

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Witteveen-Kolk Syndrome	WITKOS Sin3a-Related Intellectual Disability Syndrome Due To A Point Mutation Sin3a-Related Intellectual Disability Syndrome
Acute Promyelocytic Leukemia	Leukemia, Acute Promyelocytic Acute Myeloblastic Leukemia Type 3 Aml M3 APL Leukemia, Acute Promyelocytic, Somatic Aml With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Apml Acute Myeloblastic Leukemia 3 Acute Myeloid Leukemia With T(15 17)(Q22 Q12) (Pml/Raralpha) And Variants Acute Myeloblastic Leukaemia Type 3 Acute Myeloid Leukaemia M3 Acute Myeloid Leukemia M3 Acute Promyelocytic Leukaemia M3 Anll Myeloid Leukemia, Acute, M3 Leukemia Promyelocytic Acute Leukemia, Promyelocytic, Acute Leukemia, Acute, Promyelocytic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12926	SIN3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21756	Sin3b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28274	Sin3b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SIN3B	MGD	MGI:107158
Bos taurus	SIN3B	VGNC	VGNC:34625
Macaca mulatta	SIN3B	VGNC	VGNC:77276
Rattus norvegicus	SIN3B	RGD	RGD:1587989
Canis familiaris	SIN3B	VGNC	VGNC:46178
Felis catus	SIN3B	VGNC	VGNC:65151