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ABCB10 - ATP binding cassette subfamily B member 10 Gene

Also Known as M-ABC2; MTABC2; EST20237

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23456

About ABCB10

Cytogenetic location: 1q42.13 Genomic coordinates (GRCh38): 1:229,516,582-229,558,707 (from NCBI)

This gene has 3 transcripts (splice variants), 219 orthologues and 10 paralogues. Ubiquitous expression in bone marrow (RPKM 17.0), duodenum (RPKM 6.7) and 24 other tissues.

Summary

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The function of this mitochondrial protein is unknown. [provided by RefSeq, Jul 2008]

ABCB10 Products (1)

mRNA	Protein	Name
NM_012089.3	NP_036221.2	ATP-binding cassette sub-family B member 10, mitochondrial

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	33253225	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25063848	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	30765471	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in erythrocyte development	IMP IMP: Inferred from mutant phenotype	22085049	GOA
involved in mitochondrial unfolded protein response	IMP IMP: Inferred from mutant phenotype	28315685	GOA
involved in positive regulation of hemoglobin biosynthetic process	IMP IMP: Inferred from mutant phenotype	22085049	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	10922475	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	22655043	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABCB10 Protein Structure

ABC_membrane

ABC_tran

0
200
400
600
738 a.a.

Protein Preferred Names	Protein Names
ATP-binding cassette sub-family B member 10, mitochondrial	ABC transporter 10 protein

ABCB10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ABCB10	Q9NRK6	FECH	Homo sapiens	P22830	Comig Non-Denat Gel	30765471
Intra	ABCB10	Q9NRK6	FECH	Homo sapiens	P22830	Anti Tag CoIP	30765471

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Developmental Coordination Disorder	Motor Skills Disorders
Non-Syndromic X-Linked Intellectual Disability Arx-Related	Arx-Related Intellectual Disability Mrxarx X-Linked Mental Retardation 29 X-Linked Mental Retardation 29 And Others X-Linked Mental Retardation 32 X-Linked Mental Retardation 33 X-Linked Mental Retardation 38 X-Linked Mental Retardation 43 X-Linked Mental Retardation 76 X-Linked Mental Retardation 87 X-Linked Mental Retardation With Or Without Seizures Arx-Related Mental Retardation, X-Linked, Type 29 And Others
Anisometropia
Anemia, Sideroblastic, 1	Xlsa X-Linked Sideroblastic Anemia Hypochromic Anemia Anh1 Hereditary Iron-Loading Anemia Anemia, Sideroblastic, X-Linked Anemia, Hereditary Sideroblastic Erythroid 5-Aminolevulinate Synthase Deficiency Hereditary Sideroblastic Anemia SIDBA1 Anemia, Hypochromic Sideroblastic Anemia 1 Anemia Hypochromic X Chromosome-Linked Sideroblastic Anemia Sideroblastic Anaemia 1 X-Linked Sideroblastic Anaemia Anemia Hereditary Sideroblastic Anemia Sex-Linked Hypochromic Sideroblastic Congenital Sideroblastic Anemia Sideroblastic Anemia X-Linked Anemia, Sex-Linked Hypochromic Sideroblastic Congenital Sideroblastic Anaemia X-Linked Pyridoxine-Responsive Sideroblastic Anemia Anemia Congenital Sideroblastic Anemia, Sideroblastic, Type 1 Sex-Linked Hypochromic Sideroblastic Anaemia Autosomal Recessive Sideroblastic Anaemia Familial Sex Linked Hypochromic Anaemia
Intellectual Developmental Disorder With Short Stature And Behavioral Abnormalities	IDDSSBA
Dysgraphia	Agraphia
Protoporphyria, Erythropoietic, 1	Erythropoietic Protoporphyria Epp Ferrochelatase Deficiency Protoporphyria, Erythropoietic Erythrohepatic Protoporphyria Heme Synthetase Deficiency Autosomal Erythropoietic Protoporphyria EPP1 Protoporphyria Protoporphyria Erythropoietic
Anemia, Sideroblastic, And Spinocerebellar Ataxia	X-Linked Sideroblastic Anemia With Ataxia ASAT X-Linked Sideroblastic Anemia And Ataxia X-Linked Sideroblastic Anemia And Spinocerebellar Ataxia Anemia, Sideroblastic, With Ataxia Anemia Sideroblastic And Spinocerebellar Ataxia Pagon Bird Detter Syndrome Pagon-Bird-Detter Syndrome Xlsa-A X-Linked Sideroblastic Anaemia And Ataxia X-Linked Sideroblastic Anaemia With Ataxia Sideroblastic Anemia With Spinocerebellar Ataxia Xlsa/A Anemia, Sideroblastic, Spinocerebellar Ataxia Sideroblastic Anemia And Ataxia Anemia Sideroblastic, And Spinocerebellar Ataxia
Stereotypic Movement Disorder	Stereotypy Habit Disorder Stereotyped Repetitive Movements Stereotyped Disorder Stereotypes Nos Stereotype Habit Disorder
Acute Porphyria	Porphyrias, Hepatic Hepatic Porphyria Porphyria Hepatic Acute Intermittent Porphyria
Writing Disorder
Reading Disorder	Specific Reading Disorder Reading Dyslexia Developmental Reading Disorder
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Specific Developmental Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Cerebral Palsy	Infantile Cerebral Palsy Mixed Cerebral Palsy Palsy Cerebral Palsy, Cerebral Cerebral Palsy, Mixed

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D1063	IR-780		99.82%	Unkown
HY-RS00049	ABCB10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21085	Abcb10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27603	Abcb10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ABCB10	VGNC	VGNC:37432
Rattus norvegicus	ABCB10	RGD	RGD:1311222
Mus musculus	ABCB10	MGD	MGI:1860508
Felis catus	ABCB10	VGNC	VGNC:103727
Macaca mulatta	ABCB10	VGNC	VGNC:99826
Bos taurus	ABCB10	VGNC	VGNC:25462
Others	ABCB10	NCBI