Rspo2 - R-spondin 2 Gene

Also Known as ftls; D430027K22; 2610028F08Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 239405

Summary

Enables heparin binding activity. Acts upstream of or within several processes, including embryonic limb morphogenesis; negative regulation of odontogenesis of dentin-containing tooth; and respiratory system development. Located in cell surface and extracellular region. Is expressed in several structures, including brain; jaw; limb bud; pelvic urethra; and sensory organ. Human ortholog(s) of this gene implicated in tetraamelia syndrome 2. Orthologous to human RSPO2 (R-spondin 2). [provided by Alliance of Genome Resources, Apr 2022]

Rspo2 Products (3)

mRNA Protein Name
NM_001357956.1 NP_001344885.1 R-spondin-2 isoform 2 precursor
NM_001357957.1 NP_001344886.1 R-spondin-2 isoform 1 precursor
NM_172815.3 NP_766403.1 R-spondin-2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heparin binding IDA
IDA: Inferred from direct assay
16543246 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within bone mineralization IGI
IGI: Inferred from genetic interaction
19213727 MGI
acts upstream of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
19213727 MGI
acts upstream of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within dopaminergic neuron differentiation IMP
IMP: Inferred from mutant phenotype
24066094 MGI
acts upstream of or within embryonic forelimb morphogenesis IGI
IGI: Inferred from genetic interaction
18256198 MGI
acts upstream of or within embryonic forelimb morphogenesis IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within embryonic hindlimb morphogenesis IGI
IGI: Inferred from genetic interaction
18256198 MGI
acts upstream of or within embryonic hindlimb morphogenesis IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within epithelial tube branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within lung growth IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within negative regulation of odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
24616052 MGI
acts upstream of or within osteoblast differentiation IGI
IGI: Inferred from genetic interaction
19213727 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
18256198 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IGI
IGI: Inferred from genetic interaction
18256198 MGI
acts upstream of or within positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
18256198 MGI
acts upstream of or within trachea cartilage morphogenesis IGI
IGI: Inferred from genetic interaction
18256198 MGI
Cellular Component GO Annotation Evidence References Source
located in cell surface IDA
IDA: Inferred from direct assay
18256198 MGI
located in extracellular region IDA
IDA: Inferred from direct assay
16543246 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

R-spondin-2

  • R-spondin 2 homolog

  • cristin-2

  • cysteine-rich and single thrombospondin domain-containing protein 2

  • mCristin-2

  • roof plate-specific spondin-2

Recombinant Rspo2 Proteins

Cat. No. Product Name Accession Purity
HY-P76013 RSPO2/R-spondin-2 Protein, Mouse (HEK293, Fc) Q8BFU0 (N24-G205) ≥ 85%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12306 RSPO2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18188 Rspo2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24662 Rspo2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992300 Anti-RSPO2 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rspo2 NCBI NCBI:340419