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RSPO2 - R-spondin 2 Gene

Also Known as HHRRD; TETAMS2; CRISTIN2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 340419

About RSPO2

Cytogenetic location: 8q23.1 Genomic coordinates (GRCh38): 8:107,899,316-108,083,620 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues, 3 paralogues and is associated with 77 phenotypes. Biased expression in brain (RPKM 3.8), placenta (RPKM 3.6) and 11 other tissues.

Summary

This gene encodes a member of the R-spondin family of proteins. These proteins are secreted ligands of leucine-rich repeat containing G protein-coupled receptors that enhance Wnt signaling through the inhibition of ubiquitin E3 Ligases. A chromosomal translocation including this locus that results in the formation of a gene fusion has been identified in multiple human cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

RSPO2 Products (3)

mRNA	Protein	Name
NM_001282863.2	NP_001269792.1	R-spondin-2 isoform 2 precursor
NM_001317942.2	NP_001304871.1	R-spondin-2 isoform 3
NM_178565.5	NP_848660.3	R-spondin-2 isoform 1 precursor

Protein Preferred Names	Protein Names
R-spondin-2	R-spondin 2 homolog

RSPO2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RSPO2	Q6UXX9	KRTAP10-9	Homo sapiens	P60411	Y2H Prey Pooling	25416956
Intra	RSPO2	Q6UXX9	KRTAP10-4	Homo sapiens	P60372	Y2H Prey Pooling	25416956
Intra	RSPO2	Q6UXX9	KRTAP10-4	Homo sapiens	P60372	Validated Y2H	25416956
Intra	RSPO2	Q6UXX9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Prey Pooling	25416956
Intra	RSPO2	Q6UXX9	PLEKHF2	Homo sapiens	Q9H8W4	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RSPO2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76582	RSPO2/R-Spondin 2 Protein, Human (HEK293, Fc)	Q6UXX9-1 (Q22-G205, L186P)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Humerofemoral Hypoplasia With Radiotibial Ray Deficiency	HHRRD Hfhrtrd
Tetraamelia Syndrome 2	TETAMS2 Tetraamelia With Pulmonary Hypoplasia Tetraamelia Syndrome 2 With Pulmonary Agenesis Tetra-Amelia With Pulmonary Hypoplasia
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Fibular Aplasia Or Hypoplasia, Femoral Bowing And Poly-, Syn-, And Oligodactyly	Fuhrmann Syndrome Bowing Of The Femurs, Aplasia Or Hypoplasia Of The Fibula, And Digital Anomalies Fibular Hypoplasia Or Aplasia-Femoral Bowing-Oligodactyly Syndrome Fuhrmann-Rieger-De Sousa Syndrome FUHRS Fibular Aplasia Hypoplasia Femoral Bowing And Poly- Syn- And Oligodactyly
Craniodiaphyseal Dysplasia	CDD Schaefer Stein Oshman Syndrome Craniodiaphyseal Dysplasia, Dominant Dominantly Inherited Craniodiaphyseal Dysplasia
Ossification Of The Posterior Longitudinal Ligament Of Spine	OPLL Ossification Of The Posterior Longitudinal Ligament Of The Spine Ossification Of Posterior Longitudinal Ligament Of Spine Ossification, Posterior Longitudinal Ligament Spine
Sclerosteosis 2	SOST2 Sclerosteosis, Type 2
Keipert Syndrome	Nasodigitoacoustic Syndrome KPTS Nasodigitoacoustic Syndrome, Formerly
Diffuse Idiopathic Skeletal Hyperostosis	Hyperostosis, Diffuse Idiopathic Skeletal Ankylosing Vertebral Hyperostosis Dish Disseminated Idiopathic Skeletal Hyperostosis Forestier Disease Forestier'S Disease Hyperostosis Diffuse Idiopathic Skeletal
Endosteal Hyperostosis, Autosomal Dominant	Osteosclerosis Worth Syndrome Osteosclerosis, Autosomal Dominant Hyperostosis, Endosteal Endosteal Hyperostosis, Worth Type Worth Disease Autosomal Dominant Endosteal Hyperostosis Autosomal Dominant Osteosclerosis, Worth Type Hyperostosis Corticalis Generalisata, Benign Form Of Worth, With Torus Palatinus Autosomal Dominant Osteosclerosis Benign Form Of Worth Hyperostosis Corticalis Generalisata With Torus Platinus Worth'S Syndrome Worth Type Autosomal Dominant Osteosclerosis Hyperostosis Corticalis Generalisata, Benign Form Of Worth With Torus Palatinus Osteosclerosis, Autosomal Dominant, Worth Type WENHY Endosteal Hyperostosis Autosomal Dominant Hyperostosis Corticalis Generalisata Benign Form Of Worth With Torus Palatinus Osteosclerosis Autosomal Dominant Acquired Osteosclerosis
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12306	RSPO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18188	Rspo2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24662	Rspo2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992300	Anti-RSPO2 Antibody		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	RSPO2	VGNC	VGNC:45783
Rattus norvegicus	RSPO2	RGD	RGD:1562331
Mus musculus	RSPO2	MGD	MGI:1922667
Bos taurus	RSPO2	VGNC	VGNC:34189
Macaca mulatta	RSPO2	VGNC	VGNC:77116
Felis catus	RSPO2	VGNC	VGNC:64797
Others	RSPO2	NCBI