Synj2bp - synaptojanin 2 binding protein Gene

Mus musculus

Also known as ARIP2; OMP25; ActRIP4; D12Wsu118e

Gene ID: 24071 | Gene type: protein coding

About Synj2bp

Summary

Enables type II activin receptor binding activity. Involved in positive regulation of protein localization to cell surface; positive regulation of receptor internalization; and regulation of activin receptor signaling pathway. Acts upstream of or within Rho protein signal transduction; protein targeting; and regulation of endocytosis. Located in cell surface. Is expressed in several structures, including blood vessel; extraembryonic component; genitourinary system; neural tube; and retina. Orthologous to human SYNJ2BP (synaptojanin 2 binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Synj2bp Products(2)

mRNA	Protein	Name
NM_001309814.1	NP_001296743.1	synaptojanin-2-binding protein isoform 2
NM_025292.7	NP_079568.1	synaptojanin-2-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	10827173	MGI
enables type II activin receptor binding	IPI IPI: Inferred from physical interaction	16648306	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Rho protein signal transduction	IDA IDA: Inferred from direct assay	11882656	MGI
involved in negative regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	16648306	MGI
involved in positive regulation of activin receptor signaling pathway	IDA IDA: Inferred from direct assay	16648306	MGI
involved in positive regulation of protein localization to cell surface	IDA IDA: Inferred from direct assay	16648306	MGI
involved in positive regulation of receptor internalization	IDA IDA: Inferred from direct assay	16648306	MGI
acts upstream of or within protein targeting	IDA IDA: Inferred from direct assay	11882656	MGI
acts upstream of or within regulation of endocytosis	IDA IDA: Inferred from direct assay	11882656	MGI
NOT involved in regulation of receptor internalization	IDA IDA: Inferred from direct assay	16648306	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	16648306	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptojanin-2-binding protein

activin receptor interacting protein 2	activin receptor-interacting protein 4
mitochondrial outer membrane protein 25	outer membrane protein 25

Synj2bp Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Synj2bp	Q9D6K5	Lrp2	Mus musculus	A2ARV4	Pull Down	10827173
Intra	Synj2bp	Q9D6K5	Lrp2	Mus musculus	A2ARV4	Y2H	10827173

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-141659	CMPD-39		99.74%	Unkown
HY-141659A	(R)-CMPD-39		99.78%	Unkown
HY-RS14095	SYNJ2BP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Synj2bp	NCBI	NCBI:55333

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