Gucy1b1 - guanylate cyclase 1 soluble subunit beta 1 Gene

Rattus norvegicus

Also known as SGC; Gucy1b3

Gene ID: 25202 | Gene type: protein coding

About Gucy1b1

Summary

Enables HSP90 protein binding activity; heme binding activity; and ion binding activity. Contributes to Adenylate Cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling pathway. Located in presynaptic active zone. Part of Guanylate Cyclase complex, soluble. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Orthologous to human GUCY1B1 (Guanylate Cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Gucy1b1 Products(1)

mRNA	Protein	Name
NM_012769.2	NP_036901.2	guanylate cyclase soluble subunit beta-1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	16024662	RGD
contributes to adenylate cyclase activity	IDA IDA: Inferred from direct assay	22122229	RGD
contributes to cytidylate cyclase activity	IDA IDA: Inferred from direct assay	22122229	RGD
enables heme binding	IDA IDA: Inferred from direct assay	11688978	RGD
enables nitric oxide binding	IDA IDA: Inferred from direct assay	17098738	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11572861	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	17098738	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12388603	RGD
part of guanylate cyclase complex, soluble	IDA IDA: Inferred from direct assay	17098738	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	12388603	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16024662	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

guanylate cyclase soluble subunit beta-1

GCS-beta-1	GCS-beta-3
guanylate cyclase 1 soluble subunit beta 3	guanylate cyclase 1, soluble, beta 3
guanylate cyclase soluble subunit beta-3	guanylate cyclase, soluble, beta 1
soluble guanylate cyclase small subunit	soluble guanylyl cyclase beta

Gucy1b1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Gucy1b1	P20595	Dlg4	Rattus norvegicus	P31016	Pull Down	11572861
Intra	Gucy1b1	P20595	Dlg4	Rattus norvegicus	P31016	Anti Bait CoIP	11572861

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05920	GUCY1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gucy1b1	NCBI	NCBI:2983

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