Gucy1b1 - guanylate cyclase 1 soluble subunit beta 1 Gene

Also Known as SGC; Gucy1b3

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25202

Summary

Enables HSP90 protein binding activity; heme binding activity; and ion binding activity. Contributes to Adenylate Cyclase activity and cytidylate cyclase activity. Predicted to be involved in several processes, including cGMP biosynthetic process; cellular response to nitric oxide; and nitric oxide-cGMP-mediated signaling pathway. Located in presynaptic active zone. Part of Guanylate Cyclase complex, soluble. Is active in glutamatergic synapse and presynaptic active zone cytoplasmic component. Orthologous to human GUCY1B1 (Guanylate Cyclase 1 soluble subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Gucy1b1 Products (1)

mRNA Protein Name
NM_012769.2 NP_036901.2 guanylate cyclase soluble subunit beta-1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
16024662 RGD
contributes to adenylate cyclase activity IDA
IDA: Inferred from direct assay
22122229 RGD
contributes to cytidylate cyclase activity IDA
IDA: Inferred from direct assay
22122229 RGD
enables heme binding IDA
IDA: Inferred from direct assay
11688978 RGD
enables nitric oxide binding IDA
IDA: Inferred from direct assay
17098738 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11572861 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
17098738 RGD
Cellular Component GO Annotation Evidence References Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12388603 RGD
part of guanylate cyclase complex, soluble IDA
IDA: Inferred from direct assay
17098738 RGD
is active in presynaptic active zone cytoplasmic component IDA
IDA: Inferred from direct assay
12388603 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
16024662 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanylate cyclase soluble subunit beta-1

  • GCS-beta-1

  • GCS-beta-3

  • guanylate cyclase 1 soluble subunit beta 3

  • guanylate cyclase 1, soluble, beta 3

  • guanylate cyclase soluble subunit beta-3

  • guanylate cyclase, soluble, beta 1

  • soluble guanylate cyclase small subunit

  • soluble guanylyl cyclase beta

Gucy1b1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Gucy1b1 P20595 Dlg4 Rattus norvegicus P31016
Pull Down
11572861
Intra
Gucy1b1 P20595 Dlg4 Rattus norvegicus P31016
Anti Bait CoIP
11572861
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05920 GUCY1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gucy1b1 NCBI NCBI:2983