2. Gene
  3. Dio1 - iodothyronine deiodinase 1 Gene

Dio1 - iodothyronine deiodinase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as 5DI; ITDI1; TXDI1

Gene ID: 25430 | Gene type: protein coding

About Dio1

Summary

The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein is expressed predominantly in the liver and kidney and provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]

Dio1 Products(2)

mRNA Protein Name
NM_001324210.1 NP_001311139.1 type I iodothyronine deiodinase isoform 2
NM_021653.4 NP_067685.5 type I iodothyronine deiodinase isoform 1
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables thyroxine 5'-deiodinase activity IDA
IDA: Inferred from direct assay
1825132 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

type I iodothyronine deiodinase

DIOI

deiodinase, iodothyronine, type I

thyroxine deiodinase, type I

type 1 DI

type-I 5'-deiodinase

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B0346 Propylthiouracil Inhibitor 99.40% Unkown
Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-172661 Kylo-0603 / Phase 1
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-114557 NSC 90469 99.41% Unkown
HY-133876 4-Di-16-ASP 99.76% Unkown
HY-W331198 Tralopyril Inducer 99.70% Unkown
HY-114557R NSC 90469 (Standard) / Unkown
HY-RS03767 DIDO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS03769 DIO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dio1 NCBI NCBI:1733