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Cat. No.: HY-402216

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N-b-Hydroxyethyl oleyl imidazoline

N-b-Hydroxyethyl oleyl imidazoline is a selective enzyme inhibitor targeting DIO, with an IC₅₀ of 3.9 μM against human DIO3. N-b-Hydroxyethyl oleyl imidazoline binds to the catalytic domain of deiodinase and blocks the deiodination catalytic reaction of thyroid hormone molecules. N-b-Hydroxyethyl oleyl imidazoline can be used in studies related to the functional regulation of thyroid deiodinases.

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CAS No.: 95-38-5
Formule: C₂₂H₄₂N₂O
Masse moléculaire:350.59

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Please store the product under the recommended conditions in the Certificate of Analysis.

N-b-Hydroxyethyl oleyl imidazoline Chemical Structure

CAS No.: 95-38-5

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Description

In Vitro

N-b-Hydroxyethyl oleyl imidazoline (95-38-5) (0.032-200 μM; 3 h) inhibits the activity of human DIO3 in HEK293 cell lysates, with an IC₅₀ of 3.9 μM and an inhibition rate of 101% at the concentration of 200 μM; moreover, it achieves 50% or higher enzyme activity inhibition against all three types of deiodinases in single-point screening assays^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 95-38-5
Masse moléculaire 350.59
Formule C₂₂H₄₂N₂O
SMILES

OCCN1C(=NCC1)CCCCCCCC=CCCCCCCCC
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Olker JH, et al. Screening the ToxCast Phase 1, Phase 2, and e1k Chemical Libraries for Inhibitors of Iodothyronine Deiodinases. Toxicological sciences : an official journal of the Society of Toxicology. 2019 Apr 01;168(2):430-442. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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N-b-Hydroxyethyl oleyl imidazoline

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N-b-Hydroxyethyl oleyl imidazoline

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

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N-b-Hydroxyethyl oleyl imidazoline Related Classifications

HY-402216 Related Classifications

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