N-b-Hydroxyethyl oleyl imidazoline
N-b-Hydroxyethyl oleyl imidazoline is a selective enzyme inhibitor targeting DIO, with an IC50 of 3.9 μM against human DIO3. N-b-Hydroxyethyl oleyl imidazoline binds to the catalytic domain of deiodinase and blocks the deiodination catalytic reaction of thyroid hormone molecules. N-b-Hydroxyethyl oleyl imidazoline can be used in studies related to the functional regulation of thyroid deiodinases.
For research use only. We do not sell to patients.
- CAS No.: 95-38-5
- Formula: C22H42N2O
- Molecular Weight:350.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
N-b-Hydroxyethyl oleyl imidazoline (95-38-5) (0.032-200 μM; 3 h) inhibits the activity of human DIO3 in HEK293 cell lysates, with an IC50 of 3.9 μM and an inhibition rate of 101% at the concentration of 200 μM; moreover, it achieves 50% or higher enzyme activity inhibition against all three types of deiodinases in single-point screening assays[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 95-38-5
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Molecular Weight 350.59
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Formula C22H42N2O
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SMILES
OCCN1C(=NCC1)CCCCCCCC=CCCCCCCCC
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
N-b-Hydroxyethyl oleyl imidazoline Related Classifications
HY-402216 Related Classifications
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