MEIOB - meiosis specific with OB-fold Gene

Also Known as gs129; SPGF22; C16orf73

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 254528

About MEIOB

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:1,833,986-1,872,164 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 198 orthologues, 1 paralogue and is associated with 2 phenotypes. Restricted expression toward testis (RPKM 20.3).

Summary

Predicted to enable chromatin binding activity; single-stranded DNA 3'-5' exodeoxyribonuclease activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair via homologous recombination; fertilization; and meiotic nuclear division. Predicted to be located in cytoplasm. Implicated in spermatogenic failure 22. [provided by Alliance of Genome Resources, Apr 2022]

MEIOB Products (2)

mRNA	Protein	Name
NM_001163560.3	NP_001157032.1	meiosis-specific with OB domain-containing protein isoform 1
NM_152764.3	NP_689977.2	meiosis-specific with OB domain-containing protein isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IMP IMP: Inferred from mutant phenotype	35991565	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
meiosis-specific with OB domain-containing protein	meiosis specific with OB domains

MEIOB Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	MEIOB	Q8N635	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	28514442
Intra	MEIOB	Q8N635	GAPDHS	Homo sapiens	O14556	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Spermatogenic Failure 22	SPGF22
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spastic Paraplegia 16, X-Linked	SPG16 Hereditary Spastic Paraplegia 16 X-Linked Spastic Paraplegia Type 16 Spastic Paraplegia 16, X-Linked, Complicated X-Linked Spastic Paraplegia 16 Spastic Paraplegia 16 Spastic Paraplegia-16, X-Linked, Complicated
Spermatogenic Failure 10	SPGF10 Spermatogenic Failure With Defective Sperm Annulus
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence
Spermatogenic Failure, X-Linked, 1	Sertoli Cell-Only Syndrome Germinal Cell Aplasia Del Castillo Syndrome SPGFX1 X-Linked Spermatogenic Failure 1 Congenital Absence Of Germinal Epithelium Of Testes
Spermatogenic Failure, Y-Linked, 2	SPGFY2 Spermatogenic Failure, Nonobstructive, Y-Linked Y-Linked Spermatogenic Failure 2 Azoospermia, Nonobstructive, Y-Linked Oligozoospermia, Nonobstructive, Y-Linked Oligospermia, Nonobstructive, Y-Linked Spermatogenic Arrest, Y-Linked Nonobstructive Y-Linked Spermatogenic Failure Spermatogenic Failure Y-Linked 2 Azoospermia Non-Obstructive Y-Linked Non-Obstructive Azoospermia And Infertility Oligospermia Non-Obstructive Y-Linked Oligozoospermia Non-Obstructive Y-Linked Spermatogenic Arrest Y-Linked Spermatogenic Failure Nonobstructive Y-Linked
Kbg Syndrome	KBGS Macrodontia, Mental Retardation, Characteristic Facies, Short Stature, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Intellectual Disability, And Skeletal Anomalies Short Stature, Characteristic Facies, Macrodontia, Mental Retardation, And Skeletal Anomalies Short Stature-Characteristic Facies-Mental Retardation-Macrodontia-Skeletal Anomalies Syndrome Short Stature-Facial And Skeletal Anomalies-Intellectual Disability-Macrodontia Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08323	MEIOB Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MEIOB	RGD	RGD:1583204
Canis familiaris	MEIOB	VGNC	VGNC:54042
Bos taurus	MEIOB	VGNC	VGNC:59349
Felis catus	MEIOB	VGNC	VGNC:63448
Macaca mulatta	MEIOB	VGNC	VGNC:99523
Mus musculus	MEIOB	MGD	MGI:1922428