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SULT4A1 - sulfotransferase family 4A member 1 Gene

Also Known as NST; BRSTL1; SULTX3; BR-STL-1; DJ388M5.3; hBR-STL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 25830

About SULT4A1

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:43,824,509-43,862,513 (from NCBI)

This gene has 4 transcripts (splice variants), 243 orthologues and 12 paralogues. Biased expression in brain (RPKM 30.9), duodenum (RPKM 4.1) and 2 other tissues.

Summary

This gene encodes a member of the sulfotransferase family. The encoded protein is a brain-specific sulfotransferase believed to be involved in the metabolism of neurotransmitters. Polymorphisms in this gene may be associated with susceptibility to schizophrenia. [provided by RefSeq, Jul 2008]

SULT4A1 Products (1)

mRNA	Protein	Name
NM_014351.4	NP_055166.1	sulfotransferase 4A1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	32152050	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	19439498	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19439498	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT4A1 Protein Structure

Sulfotransfer_1

0
100
200
284 a.a.

Protein Preferred Names	Protein Names
sulfotransferase 4A1	ST4A1

SULT4A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SULT4A1	Q9BR01	TGM1	Homo sapiens	P22735	Y2H Array	32296183
Intra	SULT4A1	Q9BR01	TGM1	Homo sapiens	P22735	Y2H Prey Pooling	32296183
Intra	SULT4A1	Q9BR01	MAPK8IP3	Homo sapiens	Q9UPT6	Y2H Array	32296183
Intra	SULT4A1	Q9BR01	SULT4A1	Homo sapiens	Q9BR01	Y2H Array	32296183
Intra	SULT4A1	Q9BR01	SULT1A1	Homo sapiens	P50225	Anti Tag CoIP	33961781
Intra	SULT4A1	Q9BR01	MAPK8IP3	Homo sapiens	Q9UPT6	Anti Tag CoIP	33961781
Intra	SULT4A1	Q9BR01	SULT1A1	Homo sapiens	P50225	Anti Tag CoIP	28514442
Intra	SULT4A1	Q9BR01	MAPK8IP3	Homo sapiens	Q9UPT6	Validated Y2H	32296183
Intra	SULT4A1	Q9BR01	PIN1	Homo sapiens	Q13526	Pull Down	19439498
Intra	SULT4A1	Q9BR01	SULT4A1	Homo sapiens	Q9BR01	Y2H	19439498
Intra	SULT4A1	Q9BR01	PARVG	Homo sapiens	Q9HBI0	Anti Tag CoIP	33961781
Intra	SULT4A1	Q9BR01	MAPK8IP3	Homo sapiens	Q9UPT6	Y2H Prey Pooling	32296183
Intra	SULT4A1	Q9BR01	PARVG	Homo sapiens	Q9HBI0	Anti Tag CoIP	28514442
Intra	SULT4A1	Q9BR01	POT1	Homo sapiens	Q9NUX5	BiFC	21044950
Intra	SULT4A1	Q9BR01	SULT4A1	Homo sapiens	Q9BR01	Validated Y2H	32296183
Intra	SULT4A1	Q9BR01	PIN1	Homo sapiens	Q13526	Y2H	19439498
Intra	SULT4A1	Q9BR01	PIN1	Homo sapiens	Q13526	Anti Tag CoIP	19439498
Intra	SULT4A1	Q9BR01	SULT4A1	Homo sapiens	Q9BR01	Y2H Prey Pooling	32296183
Intra	SULT4A1	Q9BR01	POT1	Homo sapiens	Q9NUX5	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT4A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71344	SULT4A1 Protein, Human	Q9BR01 (M1-L284)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Anteroseptal Myocardial Infarction
Mixed Receptive-Expressive Language Disorder
Mitochondrial Dna Depletion Syndrome 1	MTDPS1 Mitochondrial Neurogastrointestinal Encephalopathy Syndrome, Tymp-Related Myoneurogastrointestinal Encephalopathy Syndrome Polip Syndrome Mitochondrial Dna Depletion Syndrome, Type 1 Mngie, Tymp-Related Polyneuropathy, Ophthalmoplegia, Leukoencephalopathy, And Intestinal Pseudoobstruction Mitochondrial Dna Depletion Syndrome 1, Mngie Type Mitochondrial Neurogastrointestinal Encephalomyopathy Mitochondrial Neurogastrointestinal Encephalopathy Syndrome Tymp-Related Myoneurogastrointestinal Encephalomyopathy Polyneuropathy Ophthalmoplegia Leukoencephalopathy And Intestinal Pseudoobstruction Mitochondrial Neurogastrointestinal Encephalopathy Syndrome
Neuronitis
Cercarial Dermatitis	Swimmer'S Itch Cutaneous Schistosomiasis Sea Bather'S Eruption Clam-Digger'S Itch Rice-Paddy Itch Sea Bather'S Itch Sawah Itch Schistosomal Cercarial Dermatitis
N Syndrome	NSX Intellectual Disability, Malformations, Chromosome Breakage, And Development Of T-Cell Leukemia
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Inferior Myocardial Infarction	Inferior Wall Myocardial Infarction
Schizotypal Personality Disorder	Schizotypal Personality
Phelan-Mcdermid Syndrome	Chromosome 22q13.3 Deletion Syndrome 22q13.3 Deletion Syndrome Telomeric 22q13 Monosomy Syndrome PHMDS Deletion 22q13 Syndrome 22q13.3 Deletion Deletion 22q13.3 Syndrome Monosomy 22q13 Monosomy 22q13.3 22q13 Deletion Syndrome Monosomy 22q13 Syndrome 22q13 Deletion Chromosome Deletion

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14022	SULT4A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20655	Sult4a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27166	Sult4a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SULT4A1	VGNC	VGNC:78119
Rattus norvegicus	SULT4A1	RGD	RGD:69292
Canis familiaris	SULT4A1	VGNC	VGNC:46980
Mus musculus	SULT4A1	MGD	MGI:1888971
Felis catus	SULT4A1	VGNC	VGNC:65838
Bos taurus	SULT4A1	VGNC	VGNC:35469
Others	SULT4A1	NCBI