SULT1A1 - sulfotransferase family 1A member 1 Gene

Also Known as PST; STP; STP1; P-PST; ST1A1; ST1A3; TSPST1; ts-PST; P-PST 1; HAST1/HAST2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6817

About SULT1A1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,605,258-28,623,375 (from NCBI)

This gene has 5 transcripts (splice variants), 757 orthologues and 12 paralogues. Broad expression in duodenum (RPKM 44.2), liver (RPKM 36.4) and 22 other tissues.

Summary

Sulfotransferase Enzymes catalyze the sulfate conjugation of many Hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic Enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SULT1A1 Products (10)

mRNA	Protein	Name
NM_001055.4	NP_001046.2	sulfotransferase 1A1 isoform a
NM_001394421.1	NP_001381350.1	sulfotransferase 1A1 isoform a
NM_001394422.1	NP_001381351.1	sulfotransferase 1A1 isoform a
NM_001394423.1	NP_001381352.1	sulfotransferase 1A1 isoform a
NM_001394424.1	NP_001381353.1	sulfotransferase 1A1 isoform a
NM_001394425.1	NP_001381354.1	sulfotransferase 1A1 isoform a
NM_177529.3	NP_803565.1	sulfotransferase 1A1 isoform a
NM_177530.4	NP_803566.1	sulfotransferase 1A1 isoform a
NM_177534.4	NP_803878.1	sulfotransferase 1A1 isoform a
NM_177536.5	NP_803880.2	sulfotransferase 1A1 isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables 3'-phosphoadenosine 5'-phosphosulfate binding	IDA IDA: Inferred from direct assay	12471039	GOA
enables aryl sulfotransferase activity	IDA IDA: Inferred from direct assay	12471039	GOA
enables flavonol 3-sulfotransferase activity	IDA IDA: Inferred from direct assay	20056724	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables steroid sulfotransferase activity	IDA IDA: Inferred from direct assay	16221673	GOA
enables sulfotransferase activity	IDA IDA: Inferred from direct assay	19548878	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in 3'-phosphoadenosine 5'-phosphosulfate metabolic process	IDA IDA: Inferred from direct assay	12471039	GOA
involved in estrogen metabolic process	IDA IDA: Inferred from direct assay	16221673	GOA
involved in ethanol catabolic process	IDA IDA: Inferred from direct assay	23207770	GOA
involved in flavonoid metabolic process	IDA IDA: Inferred from direct assay	20056724	GOA
acts upstream of or within sulfation	IDA IDA: Inferred from direct assay	19548878	GOA
involved in sulfation	IDA IDA: Inferred from direct assay	20056724	GOA
involved in xenobiotic metabolic process	IDA IDA: Inferred from direct assay	12471039	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SULT1A1 Protein Structure

Sulfotransfer_1

0
100
200
295 a.a.

Protein Preferred Names	Protein Names
sulfotransferase 1A1	aryl sulfotransferase 1

SULT1A1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SULT1A1	P50225	SULT2B1	Homo sapiens	O00204	Y2H Prey Pooling	25416956
Intra	SULT1A1	P50225	SULT2B1	Homo sapiens	O00204	Anti Tag CoIP	33961781
Intra	SULT1A1	P50225	SULT2B1	Homo sapiens	O00204	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SULT1A1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70969	SULT1A1 Protein, Human (His)	AAH00923.1 (M1-L295)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Mandibulofacial Dysostosis With Alopecia	MFDA
Acetaminophen Metabolism
Ceroid Lipofuscinosis, Neuronal, 3	Batten Disease Juvenile Neuronal Ceroid Lipofuscinosis Neuronal Ceroid Lipofuscinosis 3 CLN3 Jncl Spielmeyer-Vogt Disease Vogt-Spielmeyer Disease Spielmeyer-Sjogren Disease Cln3 Disease Neuronal Ceroid Lipofuscinosis, Juvenile Cln3 Disease, Juvenile Spielmeyer Sjogren Disease Vogt Spielmeyer Disease Batten-Mayou Disease Batten-Spielmeyer-Vogt Disease Cln3-Related Neuronal Ceroid-Lipofuscinosis Juvenile Batten Disease Juvenile Cerebroretinal Degeneration Classic Juvenile Ncl Classic Juvenile Neuronal Ceroid Lipofuscinosis Juvenile Ncl Lipofuscinosis, Ceroid, Neuronal, Type 3
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Endometrial Cancer	Endometrial Carcinoma Endometrial Neoplasm Malignant Neoplasm Of Endometrium Endometrioid Carcinoma Endometrial Neoplasms Carcinoma, Endometrioid Endometrial Cancer, Familial Endometrial Carcinoma, Somatic Endometrial Cancer, Susceptibility To Endometrial Ca Malignant Endometrial Neoplasm Neoplasm Of Endometrium Primary Malignant Neoplasm Of Endometrium Tumor Of Endometrium Carcinoma Of The Endometrium Endometrioid Carcinoma Of Female Reproductive System ENDMC Carcinoma Endometrioid Endometrial Cancers Cancer, Endometrial Uterine Corpus Cancer
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119323	7-Azido-4-methylcoumarin		98.90%	Unkown
HY-175266	MI1013		99.10%	Unkown
HY-RS14013	SULT1A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14016	SULT1B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14019	SULT1E1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18107	Sult1e1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18583	Sult1b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20222	Sult1a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24581	Sult1e1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25068	Sult1b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26729	Sult1a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SULT1A1	RGD	RGD:3767
Mus musculus	SULT1A1	MGD	MGI:102896
Others	SULT1A1	NCBI