ADGRD1 - adhesion G protein-coupled receptor D1 Gene

Also Known as PGR25; GPR133

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 283383

About ADGRD1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,953,907-131,141,469 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 42 paralogues. Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues.

Summary

The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

ADGRD1 Products (2)

mRNA	Protein	Name
NM_001330497.2	NP_001317426.1	adhesion G-protein coupled receptor D1 isoform 2
NM_198827.5	NP_942122.2	adhesion G-protein coupled receptor D1 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled receptor activity	IDA IDA: Inferred from direct assay	22025619	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22025619	GOA
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	22025619	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22025619	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADGRD1 Protein Structure

Laminin_G_3

GPS

7tm_2

0
200
400
600
800
874 a.a.

Protein Preferred Names	Protein Names
adhesion G-protein coupled receptor D1	G-protein coupled receptor 133

Recombinant ADGRD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76961	GPR133 Protein, Human (HEK293, His)	Q6QNK2-1/NP_942122.2 (V26-S570)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Usher Syndrome, Type Iic	Usher Syndrome Type 2c USH2C Usher Syndrome, Type 2c Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic Usher Syndrome Type Iic Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic Usher Syndrome 2c Usher'S Syndrome Type 2c Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic
Polymicrogyria, Bilateral Frontoparietal	Bilateral Frontoparietal Polymicrogyria BFPP Cerebellar Ataxia With Neuronal Migration Defect
Intellectual Developmental Disorder, Autosomal Dominant 33	MRD33 Autosomal Dominant Non-Syndromic Intellectual Disability 33 Mental Retardation, Autosomal Dominant 33 Autosomal Dominant Intellectual Developmental Disorder 33 Autosomal Dominant Mental Retardation 33 Mental Retardation, Autosomal Dominant, Type 33
Glioblastoma	Glioblastoma Multiforme Gbm Adult Glioblastoma Multiforme Grade Iv Adult Astrocytic Tumor Primary Glioblastoma Multiforme Spongioblastoma Multiforme Adult Glioblastoma Primary Glioblastoma
Vibratory Urticaria	Vibratory Angioedema Dermodistortive Urticaria VBU Ddu Angioedema, Vibratory
Brachial Plexus Lesion	Brachial Plexus Injuries Brachial Plexus Lesions
Usher Syndrome Type 2	Ush2 Usher Syndrome Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-177108	AP-503	Agonist	99.84%	Unkown
HY-175232	GL64		98.80%	Unkown
HY-RS00348	ADGRD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21814	Adgrd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28330	Adgrd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADGRD1	MGD	MGI:3041203
Canis familiaris	ADGRD1	VGNC	VGNC:52918
Macaca mulatta	ADGRD1	VGNC	VGNC:99877
Bos taurus	ADGRD1	VGNC	VGNC:53887
Felis catus	ADGRD1	VGNC	VGNC:80420
Rattus norvegicus	ADGRD1	RGD	RGD:1594795
Others	ADGRD1	NCBI