ADGRD1 - adhesion G protein-coupled receptor D1 Gene

Homo sapiens

Also known as PGR25; GPR133

Gene ID: 283383 | Gene type: protein coding

About ADGRD1

Cytogenetic location: 12q24.33 Genomic coordinates (GRCh38): 12:130,953,907-131,141,469 (from NCBI)

This gene has 16 transcripts (splice variants), 200 orthologues and 42 paralogues. Broad expression in placenta (RPKM 7.4), lung (RPKM 6.8) and 20 other tissues.

Summary

The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010]

ADGRD1 Products(2)

mRNA	Protein	Name
NM_001330497.2	NP_001317426.1	adhesion G-protein coupled receptor D1 isoform 2
NM_198827.5	NP_942122.2	adhesion G-protein coupled receptor D1 isoform 1 precursor

ADGRD1 Protein Structure

Laminin_G_3

GPS

7tm_2

0
200
400
600
800
874 a.a.

Protein Preferred Names

Protein Names

adhesion G-protein coupled receptor D1

G-protein coupled receptor 133

Recombinant ADGRD1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76961	GPR133 Protein, Human (HEK293, His)	Q6QNK2-1/NP_942122.2 (V26-S570)	≥95%

Related Diseases

Diseases

Alias

Usher Syndrome, Type Iic

Usher Syndrome Type 2c	USH2C
Usher Syndrome, Type 2c	Usher Syndrome, Type Iic, Gpr98/Pdzd7 Digenic
Usher Syndrome Type Iic	Usher Syndrome, Type 2c, Gpr98/Pdzd7 Digenic
Usher Syndrome 2c	Usher'S Syndrome Type 2c
Usher Syndrome Type Iic Gpr98/Pdzd7 Digenic

Polymicrogyria, Bilateral Frontoparietal

Bilateral Frontoparietal Polymicrogyria	BFPP
Cerebellar Ataxia With Neuronal Migration Defect

Intellectual Developmental Disorder, Autosomal Dominant 33

MRD33	Autosomal Dominant Non-Syndromic Intellectual Disability 33
Mental Retardation, Autosomal Dominant 33	Autosomal Dominant Intellectual Developmental Disorder 33
Autosomal Dominant Mental Retardation 33	Mental Retardation, Autosomal Dominant, Type 33

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Vibratory Urticaria

Vibratory Angioedema	Dermodistortive Urticaria
VBU	Ddu
Angioedema, Vibratory

Brachial Plexus Lesion

Brachial Plexus Injuries

Brachial Plexus Lesions

Usher Syndrome Type 2

Ush2	Usher Syndrome Type Ii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00348	ADGRD1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ADGRD1	MGD	MGI:3041203
Canis familiaris	ADGRD1	VGNC	VGNC:52918
Macaca mulatta	ADGRD1	VGNC	VGNC:99877
Bos taurus	ADGRD1	VGNC	VGNC:53887
Felis catus	ADGRD1	VGNC	VGNC:80420
Rattus norvegicus	ADGRD1	RGD	RGD:1594795
Others	ADGRD1	NCBI

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