country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Art. -Nr.: HY-186252

Copy Link Print Information

GPR133 agonist 1

GPR133 agonist 1 is an orally active GPR133/ADGRD1 agonist with an EC₅₀ of 1.6 nM (293T cells). GPR133 agonist 1 activates GPR133, thereby regulating the downstream cAMP signaling pathway. GPR133 agonist 1 enhances muscle strength and endurance in mice. GPR133 agonist 1 can be used in research related to muscular atrophy, myasthenia, sarcopenia, erectile dysfunction, vestibular dysfunction, obesity, and non-alcoholic fatty liver disease.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3103571-04-3
Formel: C₂₅H₃₄N₄O₃
Molecular Weight:438.56

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

GPR133 agonist 1 Chemical Structure

CAS. Nr.: 3103571-04-3

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

GPR133 agonist 1 (Compound 1) exhibits potent GPR133 agonist activity in HEK293 cells overexpressing GPR133, with an EC₅₀ of 1.6 nM^[1].
GPR133 agonist 1 (1 μM; 15 min) exhibits significantly improved stability in mouse liver microsomes, with 90% remaining after incubation at 1 μM for 15 min^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

GPR133 agonist 1 (20 mg/kg; p.o.; daily; 5 days) increases mouse muscle strength and endurance, with an average suspension stay time of 53.6 seconds, which is significantly greater than that of the positive control AP503^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57BL/6 (male, 5 weeks old, 16-20g)^[1]
Dosage:

20 mg/kg
Administration:

p.o.; daily; 5 days
Result:

Increased average suspension stay time to 53.6 seconds.

Chemical Information

CAS. Nr. 3103571-04-3
Molecular Weight 438.56
Formel C₂₅H₃₄N₄O₃
SMILES

O=C(N(C)C)C1=CC=C(N2CCN(CC2)CC)C(NC(COC3=CC=C(C)C=C3C)=O)=C1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Li Zheng, et al. A novel benzamide derivative, its preparation method and its use as medicine. CN120247837A. 2025-07-04.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

Angebot einholen Auf Lager

Other size

Angebot einholen