NPW - neuropeptide W Gene

Homo sapiens

Also known as L8; L8C; PPL8; PPNPW

Gene ID: 283869 | Gene type: protein coding

About NPW

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:2,019,785-2,020,755 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 1 paralogue. Biased expression in liver (RPKM 2.8), stomach (RPKM 0.8) and 1 other tissue.

Summary

The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the Adenylate Cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]

NPW Products(1)

mRNA	Protein	Name
NM_001099456.3	NP_001092926.2	neuropeptide W preproprotein

NPW Protein Structure

NPBW

0
100
165 a.a.

Protein Preferred Names

Protein Names

neuropeptide W

hPPL8

Related Diseases

Diseases

Alias

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108624	CYM 50769	Antagonist	98.68%	Unkown
HY-RS09509	NPW Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NPW	RGD	RGD:727858
Macaca mulatta	NPW	VGNC	VGNC:75288
Mus musculus	NPW	MGD	MGI:2685781

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