RGMB - repulsive guidance molecule BMP co-receptor b Gene

Also Known as DRAGON

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 285704

About RGMB

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:98,768,632-98,796,494 (from NCBI)

This gene has 7 transcripts (splice variants), 206 orthologues and 2 paralogues. Ubiquitous expression in brain (RPKM 10.1), skin (RPKM 10.1) and 24 other tissues.

Summary

RGMB is a glycosylphosphatidylinositol (GPI)-anchored member of the repulsive guidance molecule family (see RGMA, MIM 607362) and contributes to the patterning of the developing nervous system (Samad et al., 2005 [PubMed 15671031]).[supplied by OMIM, Apr 2009]

RGMB Products (5)

mRNA Protein Name
NM_001012761.3 NP_001012779.2 repulsive guidance molecule B isoform 2
NM_001366508.1 NP_001353437.1 repulsive guidance molecule B isoform 1 precursor
NM_001366509.1 NP_001353438.1 repulsive guidance molecule B isoform 2
NM_001366510.1 NP_001353439.1 repulsive guidance molecule B isoform 2
NM_001366511.1 NP_001353440.1 repulsive guidance molecule B isoform 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25938661 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RGMB Protein Structure

RGM_N

RGM_N: Repulsive guidance molecule (RGM) N-terminus (54 - 221)

RGM_C

RGM_C: Repulsive guidance molecule (RGM) C-terminus (226 - 407)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 437 a.a.
Protein Preferred Names Protein Names

repulsive guidance molecule B

  • DRG11-responsive axonal guidance and outgrowth of neurite

RGMB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Cross
RGMB Q6NW40 Neo1 Mus musculus P97798
SAXS
25938661
Cross
RGMB Q6NW40 Neo1 Mus musculus P97798
GMS
25938661
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RGMB Proteins

Cat. No. Product Name Accession Purity
HY-P76573 RGMB Protein, Human (HEK293, His) Q6NW40/J3KNF6 (G46-N413) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hemochromatosis Type 2

  • Juvenile Hemochromatosis

  • Juvenile Hereditary Hemochromatosis

  • Hfe2

  • Jhh

  • Hemochromatosis Juvenile

  • Iron Overload Disease Juvenile

  • Hemochromatosis, Juvenile

  • Hemochromatosis, Type 2

  • Hemochromatosis

  • Hemochromatosis, Type 1
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11895 RGMB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18257 Rgmb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24737 Rgmb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990164 Anti-Mouse RGMb Antibody (307.9D1) Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus RGMB RGD RGD:1595392
Macaca mulatta RGMB VGNC VGNC:76843
Felis catus RGMB VGNC VGNC:102308
Mus musculus RGMB MGD MGI:1916049
Bos taurus RGMB VGNC VGNC:55306
Others RGMB NCBI