RGMB Protein, Human (HEK293, His)

RGMB Protein, a member of the repulsive guidance molecule (RGM) family, plays a crucial role in shaping the developing nervous system by contributing to its patterning. Functioning as a bone morphogenetic protein (BMP) coreceptor, RGMB enhances BMP signaling, highlighting its involvement in pivotal cellular processes. Additionally, RGMB promotes neuronal adhesion and may exert an inhibitory effect on neurite outgrowth. Existing as a homooligomer, RGMB interacts with DRGX and forms functional complexes with BMP2, BMP4, ACVR1, BMPR1A, BMPR1B, and ACVR2B, orchestrating a network of interactions critical for cellular signaling. Notably, its complex with the receptor NEO1/neogenin adopts a heterotetrameric structure with a 2:2 stoichiometry, where RGM molecules act as staples, bringing two NEO1 receptors together without direct self-interaction. This unique arrangement facilitates downstream signaling activation via the RhoA pathway, emphasizing RGMB's multifaceted role in orchestrating intricate molecular events during neural development.