Grik1 - glutamate ionotropic receptor kainate type subunit 1 Gene

Rattus norvegicus

Also known as GluK1; GluR5

Gene ID: 29559 | Gene type: protein coding

About Grik1

Summary

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. The subunit encoded by this gene is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to alter the properties of ion flow. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene. [provided by RefSeq, Jul 2008]

Grik1 Products(3)

mRNA	Protein	Name
NM_001111114.1	NP_001104584.1	glutamate receptor ionotropic, kainate 1 isoform 3
NM_001111117.1	NP_001104587.1	glutamate receptor ionotropic, kainate 1 isoform 1 precursor
NM_017241.2	NP_058937.1	glutamate receptor ionotropic, kainate 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IPI IPI: Inferred from physical interaction	12597860	RGD
enables extracellularly glutamate-gated ion channel activity	IDA IDA: Inferred from direct assay	1977421	RGD
enables glutamate binding	IDA IDA: Inferred from direct assay	12533604	RGD
enables glutamate-gated calcium ion channel activity	IDA IDA: Inferred from direct assay	11425885	RGD
enables glutamate-gated receptor activity	IDA IDA: Inferred from direct assay	1322826	RGD
contributes to heterocyclic compound binding	IPI IPI: Inferred from physical interaction	12904467	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	16540562	RGD
enables kainate selective glutamate receptor activity	IDA IDA: Inferred from direct assay	12873388	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	1373382	RGD
enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	1373382	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12597860	RGD
enables scaffold protein binding	IDA IDA: Inferred from direct assay	12597860	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in ionotropic glutamate receptor signaling pathway	IDA IDA: Inferred from direct assay	17395219	RGD
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	12597860	RGD
involved in negative regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12533604	RGD
involved in negative regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	17395219	RGD
involved in nervous system development	IMP IMP: Inferred from mutant phenotype	1977421	RGD
involved in positive regulation of synaptic transmission, GABAergic	IDA IDA: Inferred from direct assay	12533604	RGD
involved in regulation of short-term neuronal synaptic plasticity	IDA IDA: Inferred from direct assay	17395219	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendrite	IDA IDA: Inferred from direct assay	15844209	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	16360275	RGD
part of ionotropic glutamate receptor complex	IDA IDA: Inferred from direct assay	16540562	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15844209	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16360275	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	10627597	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	15844209	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutamate receptor ionotropic, kainate 1

glutamate receptor 5

Grik1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Grik1	P22756	Grik5	Rattus norvegicus	Q63273	Pull Down	34706237
Intra	Grik1	P22756	Grik2	Rattus norvegicus	P42260	FRET	34706237
Intra	Grik1	P22756	Grik1	Rattus norvegicus	P22756	3D-EM	34706237
Intra	Grik1	P22756	Grik2	Rattus norvegicus	P42260	Pull Down	34706237
Intra	Grik1	P22756	Grik5	Rattus norvegicus	Q63273	FRET	34706237
Intra	Grik1	P22756	Grik1	Rattus norvegicus	P22756	GMS	34706237
Intra	Grik1	P22756	Grik1	Rattus norvegicus	P22756	Solution Sedimentation	17115050
Intra	Grik1	P22756	Grik3	Rattus norvegicus	P42264	Pull Down	34706237

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05798	GRIK1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22540	Grik1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grik1	NCBI	NCBI:2897

Name
Email *

	Sorry, but the email address you supplied was invalid.