EPN1 - epsin 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 29924

About EPN1

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,675,226-55,709,533 (from NCBI)

This gene has 7 transcripts (splice variants), 258 orthologues and 5 paralogues. Ubiquitous expression in duodenum (RPKM 31.4), stomach (RPKM 31.2) and 25 other tissues.

Summary

This gene encodes a member of the epsin protein family. The encoded protein binds clathrin and is involved in the endocytosis of clathrin-coated vesicles. Loss of function of this gene is associated with reduced tumor growth and progression in certain Cancer types. [provided by RefSeq, Mar 2016]

EPN1 Products (4)

mRNA	Protein	Name
NM_001130071.2	NP_001123543.1	epsin-1 isoform a
NM_001130072.2	NP_001123544.1	epsin-1 isoform b
NM_001321263.2	NP_001308192.1	epsin-1 isoform d
NM_013333.4	NP_037465.2	epsin-1 isoform c

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables molecular sequestering activity	EXP EXP: Inferred from Experiment	11161217	GOA
enables molecular sequestering activity	IPI IPI: Inferred from physical interaction	11161217	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18199683	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of sprouting angiogenesis	IGI IGI: Inferred from genetic interaction	28717225	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EPN1 Protein Structure

ENTH

UIM

0
100
200
300
400
500
576 a.a.

Protein Preferred Names	Protein Names
epsin-1	EH domain-binding mitotic phosphoprotein

EPN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83033	Epsin 1 Antibody (YA2778)	WB, ICC/IF	Human, Mouse, Rat
HY-P83033A	Epsin 1 Antibody (YA2778)(PBS only)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Adult Spinal Cord Ependymoma
Erythrocytosis, Familial, 1	ECYT1 Pfcp Primary Familial And Congenital Polycythemia Familial Erythrocytosis 1 Familial Erythrocytosis Polycythemia, Primary Familial And Congenital Autosomal Dominant Benign Erythrocytosis Familial Erythrocytosis Type 1 Congenital Erythrocytosis Due To Erythropoietin Receptor Mutation Congenital Polycythemia Due To Erythropoietin Receptor Mutation Primary Congenital Erythrocytosis Primary Familial Polycythemia Erythrocytosis, Autosomal Dominant Benign Erythrocytosis, Somatic Autosomal Dominant Familial Erythrocytosis-1 Erythrocytosis Autosomal Dominant Benign Familial Primary Polycythemia Familial Erythrocytosis, 1 Erythrocytosis, Familial, Type 1
Hypercholesterolemia, Familial, 4	Hypercholesterolemia, Autosomal Recessive Arh FHCL4 Autosomal Recessive Hypercholesterolemia Arh1 Arh2 Autosomal Recessive Hypercholesterolemia 1 Autosomal Recessive Hypercholesterolemia 2 Fhcb1 Fhcb2 Hypercholesterolemia, Autosomal Recessive, 1, Formerly Arh1, Formerly Fhcb1, Formerly Hypercholesterolemia, Autosomal Recessive, 2, Formerly Arh2, Formerly Fhcb2, Formerly Familial Autosomal Recessive Hypercholesterolemia Hypercholesterolemia, Familial, Autosomal Recessive Hypercholesterolemia, Familial, Type 4

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04443	EPN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EPN1	MGD	MGI:1333763
Bos taurus	EPN1	VGNC	VGNC:28546
Felis catus	EPN1	VGNC	VGNC:61912
Rattus norvegicus	EPN1	RGD	RGD:619772
Macaca mulatta	EPN1	VGNC	VGNC:72084
Canis familiaris	EPN1	VGNC	VGNC:40419
Others	EPN1	NCBI