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Epsin 1 Antibody (YA2778)(PBS only)

(Synonyms: Epsin 1)

Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.

For research use only. We do not sell to patients.
  • Host:

    Rabbit

  • Isotype:

    IgG

  • Application:

    WB, ICC/IF

  • Reactivity :

    Human, Mouse, Rat

  • Formulation:

    Supplied in PBS, pH 7.4.

  • Conjugation:
    Non-conjugated
  • Epsin 1 Antibody (YA2778)(PBS only) Product Image
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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Use of MCE Products

Applications

Application
WB Info
WB: Western Blot
ICC/IF Info
ICC/IF: Immunocytochemistry/
Immunofluorescence
Dilution Ratio 1:500-1:1000 1:50-1:100

Product Details

Description

Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.

  • Host Rabbit
  • Species Reactivity
    Human, Mouse, Rat
  • Observed Molecular Weight
    Observed band size: 90 kDa Info
    Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
  • Calculated Molecular Weight Predicted band size: 60 kDa
Immunogen

A synthetic peptide of human Epsin 1

Purification

Affinity Purified

Conjugation

Non-conjugated

Isotype

IgG

Product Properties

  • Appearance

    Liquid

  • Formulation

    Supplied in PBS, pH 7.4.

  • Storage & Stability

    Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

  • Shipping

    Shipping with blue ice.

Background

  • Function

    Epsin 1 binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis[1][2].

  • Subcellular Localization

    Cytoplasm; Cell membrane; Peripheral membrane protein; Nucleus; Membrane, clathrin-coated pit

  • Isoforms & Post-Translational Modification

    Q9Y6I3 has 3 isomers: Q9Y6I3-2: 60293 Da (predicted); Q9Y6I3-1: 69040 Da (predicted); Q9Y6I3-3: 57504 Da (predicted).
    Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation;Ubiquitinated

  • Subunit

    Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1 (By similarity). Binds ubiquitinated proteins (By similarity). Binds AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2. Interacts with REPS2; the interaction is direct (PubMed:10393179, PubMed:10557078, PubMed:10764745). Interacts with EPS15; the interaction is direct (PubMed:10393179, PubMed:10764745). Interacts with ENTREP1 (PubMed:34927784)

  • SwissProt ID

    Q9Y6I3

  • Gene ID
    29924 [NCBI]
  • Synonyms

    Epsin 1

  • Research Field

    Signal Transduction

Epsin 1 Antibody (YA2778)(PBS only) Related Classifications

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100 mg

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Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
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  • Epsin 1 Antibody (YA2778)(PBS only) Product Image