Epsin 1 Antibody (YA2778)

Cat. No.: HY-P83033: Data Sheet COA
SDS
User Guide for Antibodies
FAQs
Technical Support

Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.

For research use only. We do not sell to patients.

Size	Stock	Quantity
20 μL	In-stock	Estimated Time of Arrival: December 31
50 μL	In-stock	Estimated Time of Arrival: December 31
100 μL	In-stock	Estimated Time of Arrival: December 31
250 μL	Get quote

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Epsin 1 Antibody (YA2778) Featured Recommendations:

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation
References

Description

Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.

Host

Rabbit

Clonality

Recombinant,Monoclonal

Molecular Weight

Predicted band size: 60 kDa;

Observed band size: 90 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

Q9Y6I3

Gene ID

29924 [NCBI]

Immunogen

A synthetic peptide of human Epsin 1

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
ICC/IF ICC/IF: Immunocytochemistry/Immunofluorescence	1:50-1:100

Sensitivity	Endogenous	Purity	Affinity Purified
Conjugation	Non-conjugated	Modification	Unmodified
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis (PubMed:10393179, PubMed:10557078)

Subcellular Localization：Cytoplasm; Cell membrane; Peripheral membrane protein; Nucleus; Membrane, clathrin-coated pit

Isoforms & Post-Translational Modification：Q9Y6I3 has 3 isomers: Q9Y6I3-2: 60293 Da (predicted); Q9Y6I3-1: 69040 Da (predicted); Q9Y6I3-3: 57504 Da (predicted).
Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation;Ubiquitinated

Subunit：Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1 (By similarity). Binds ubiquitinated proteins (By similarity). Binds AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2. Interacts with REPS2; the interaction is direct (PubMed:10393179, PubMed:10557078, PubMed:10764745). Interacts with EPS15; the interaction is direct (PubMed:10393179, PubMed:10764745). Interacts with ENTREP1 (PubMed:34927784)

Database

Entrez Gene: 29924 Human ; 13854 Mouse ; 117277 Rat

SwissProt: Q9Y6I3 Human ; Q80VP1 Mouse ; O88339 Rat

OMIM: 607262 Human

Research Field

Signal Transduction

Synonyms

Epsin 1

Documentation

Select Batch:

Data Sheet (232 KB) SDS (251 KB)

COA (206 KB)

User Guide for Antibodies (1077 KB)

References

[1]. /biology-dictionary/mcf7-cell.html [Content Brief]

Epsin 1 Antibody (YA2778) Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Epsin 1 Antibody (YA2778)

Epsin 1 Antibody (YA2778) Featured Recommendations:

Product Detail

Background

Documentation

References

Epsin 1 Antibody (YA2778) Related Classifications

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