Epsin 1 Antibody (YA2778)
(Synonyms: Epsin 1)
Based on 1 Customer Validation
Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, ICC/IF
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Reactivity :
Human, Mouse, Rat
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Formulation:
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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ICC/IF
ICC/IF: Immunocytochemistry/
Immunofluorescence |
|---|---|---|
| Dilution Ratio | 1:500-1:1000 | 1:50-1:100 |
Product Details
Epsin 1 Antibody (YA2778) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Epsin 1.
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Host Rabbit
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Clonality Recombinant,Monoclonal
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Species ReactivityHuman, Mouse, Rat
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Observed Molecular WeightObserved band size: 90 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 60 kDa
Entrez Gene: 29924 Human ; 13854 Mouse ; 117277 Rat
SwissProt: Q9Y6I3 Human ; Q80VP1 Mouse ; O88339 Rat
OMIM: 607262 Human
A synthetic peptide of human Epsin 1
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in 50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
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Concentration
Batch-dependent, Please check the COA for the concentration of each lot. Check Lot Concentration
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Shipping
Shipping with blue ice.
Background
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Function
Epsin 1 binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis[1][2].
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Subcellular Localization
Cytoplasm; Cell membrane; Peripheral membrane protein; Nucleus; Membrane, clathrin-coated pit
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Isoforms & Post-Translational Modification
Q9Y6I3 has 3 isomers: Q9Y6I3-2: 60293 Da (predicted); Q9Y6I3-1: 69040 Da (predicted); Q9Y6I3-3: 57504 Da (predicted).
Phosphorylated on serine and/or threonine residues in mitotic cells. Phosphorylation reduces interaction with REPS2, AP-2 and the membrane fraction. Depolarization of synaptosomes results in dephosphorylation;Ubiquitinated -
Subunit
Monomer. Binds clathrin, ZBTB16/ZNF145 and ITSN1 (By similarity). Binds ubiquitinated proteins (By similarity). Binds AP2A1 and AP2A2. Interacts with RALBP1 in a complex also containing NUMB and TFAP2A during interphase and mitosis. Interacts with AP2B1. Interacts with UBQLN2. Interacts with REPS2; the interaction is direct (PubMed:10393179, PubMed:10557078, PubMed:10764745). Interacts with EPS15; the interaction is direct (PubMed:10393179, PubMed:10764745). Interacts with ENTREP1 (PubMed:34927784)
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SwissProt ID
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Synonyms
Epsin 1
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Research Field
Signal Transduction
Documentation
References
[1]. Nakashima S, et al. Small G protein Ral and its downstream molecules regulate endocytosis of EGF and insulin receptors. EMBO J. 1999 Jul 1;18(13):3629-42. [Content Brief]
[2]. Morinaka K, et al. Epsin binds to the EH domain of POB1 and regulates receptor-mediated endocytosis. Oncogene. 1999 Oct 21;18(43):5915-22. [Content Brief]
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